Financial Disclosures Toric IOL Selec-on and Posi-oning
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1 Financial Disclosures Toric IOL Selec-on and Posi-oning Abbo$ Medical Op/cs Inc. L Guided by Intraopera-ve Aberrometry Allergan, Inc. - C, L Kathryn M. Hatch, M.D. Assistant Clinical Professor of Ophthalmology, Warren Alpert Medical School of Brown University Talamo Hatch Laser Eye Consultants Waltham, MA April 29, 2014 IOP Ophthalmics C,L Toric IOL Intraopera-ve Aberrometry Intraocular lens designed to decrease postopera-ve as-gma-sm Mul-ple manufacturers Alcon AbboR Medical Op-cs Staar Bausch & Lomb Real- -me aphakic readings Assist with IOL choice Power calcula-on Toric calcula-on As-gma-sm management with Toric IOLs alignment and LRIs
2
3 Value? Intraopera-ve Aberrometry To our knowledge, there is no peer- reviewed literature evalua-ng the use of aberrometry with Toric IOLs Methods Non- randomized retrospec-ve compara-ve trial Private prac-ce se\ng 2 surgeons Methods Baseline Characteris-cs of Intraopera-ve Aberrometry vs Toric Calculator Groups Aberrometry group (n= 37 eyes) Cylinder power and axis of placement determined by ORA aphakic refrac-on Placement refined by pseudophakic refrac-on Toric calculator ( tradi-onal method ) group (n=27 eyes) Cylinder power and axis of placement determined by standard biometry and toric calculator Primary Outcome Measurement Post- op refrac-ve cylinder Aberrometry group: 37 cases Mean pre- op keratometric as-gma-sm: 1.83 D ± 0.79 D Range 0.74 D to 3.77 D Mean postop -meframe: 58 days (2 months) Range: 15 to 132 days Lenses implanted SN6AT3: 18 SN6AT4: 4 SN6AT5: 5 SN6AT6: 2 SN6AT7: 1 SN6AT8: 2 ZCT150: 3 ZCT225: 1 ZCT300: 1 Non- ORA group: 27 cases Mean pre- op keratometric as-gma-sm: 1.59 D ± 0.69 D Range 0.69 D to 4.10 D Mean postop -meframe: 60 days (2 months) Range: 29 to 119 days Lenses implanted SN6AT3: 18 SN6AT4: 2 SN6AT5: 6 SN6AT7: 1
4 Preopera-ve Keratometric As-gma-sm Versus Aphakic Aberrometry Measurement (n=37) Preopera-ve Keratometric As-gma-sm Toric Calculator Group (n=27) Preop Keratometric Cylinder Measured Aphakic Cylinder Preop Keratometric Cylinder Altered Decision Making in OR; Aberrometry Group Number of Rota-ons Made Amer 1 st Toric Lens Posi-oning Pseudophakic Measurement Toric IOL power Changed 24% of the -me (9/37) Spherical IOL power Changed 35% of the -me (13/37) > 3 Rota/ons, 8% No Rota/ons, 68% <= 3 Rota/ons, 92% No rota/ons were necessary in 2/3 rd of aberrometry cases
5 No Rota-ons Necessary in 2/3 cases Postopera-ve Residual Refrac-ve As-gma-sm No rota-ons; 68% This number may also be aided by intraop info provided to surgeon via re-cule and aphakic refrac-on/vector analysis 100% 80% 60% 40% 38% 33% 78% 74% 86% 89% 95% non ORA (n=27) ORA (n=37) 3 rota-ons; 92% 20% 22% > 3 rota-ons; 8% 0% Mean Standard Devia/on p- value Non ORA 0.68 D + / D.0153 ORA 0.46 D + / D sta*s*cally significant Post- Opera-ve Residual Refrac-ve As-gma-sm (RRA) Non Aberrometry Group Pre- op and Post- op As-gma-sm 0.25 D RRA 0.50 D RRA 0.75 D RRA 1.00 D RRA % pa-ents Aberrometry group n=37 mean: 0.46 D ± % 78% 86% 95% 57% reduc-on in cylinder % pa-ents Non- Aberrometry group n=27 mean: 0.68 D ± 0.34 Results of Alcon FDA Trial n=244 mean: 0.55 D ± 0.50 D 22% 33% 74% 89% % % Chance of a pa/ent being in a lower postopera/ve residual refrac/ve range increases when intraopera/ve aberrometry is used p- value:.0130 Preop Keratometric Cylinder Postopera-ve Refrac-ve Cylinder
6 Aberrometry Group Pre- op and Post- op As-gma-sm 100% UCDVA Results *Eyes targeted for distance only, no ocular disease 85% 94% 91% 75% reduc-on in cylinder (p- value:.0027) 80% 60% 40% 48% 39% 67% 70% non ORA (n=23) ORA (n=33) 26% 20% 9% 6% 0% 20/20 20/25 20/30 20/40 > 20/40 Preop Keratometric Cylinder Postopera-ve Refrac-ve Cylinder Mean Standard Devia/on Min Max Non ORA logmar equivalent / ORA logmar equivalent / Cylinder Predic-on To Intended Target Review of an Aberrometry Case in which ORA was not followed 100.0% 94.6% 95.5% 97.3% 90.0% 80.0% 79.7% 75.7% Female, 61 years old 60.0% 40.0% 51.4% 64.3% AMO B&L ORA IOLMaster k s: 177 Autorefrac-on k s: 87 Other device k s: 171 Target refrac-on: plano 20.0% 0.0% Preop plan to implant 13.5 D SN6AT3
7 Review of an Aberrometry Case in which ORA was not followed Review of an Aberrometry Case in which ORA was not followed ORA showed T3 with > 1 D residual as/gma/sm during 1 st aphakic measurement ORA suggested higher cylindrical power during this measurement Review of an Aberrometry Case in which ORA was not followed Limita-ons T3 implanted; ORA shows 1.59 D of residual as/gma/sm Cost OR -me Learning Curve IOP Bubbles Lid speculum Pa/ent s manifest refrac/on at 15 days postop was x 174
8 Conclusions You don t always get it right the first -me Toric power changed in 25% > 1 rota-onal adjustment in 1/3 Intraop aberrometry reduces absolute post- opera-ve RRA and improves UCVA Aberrometry (in our hands) 2.5 x more likely to achieve 0.50 D residual refrac-ve as-gma-sm
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