The following portfolio data for the Franklin Templeton funds is made available to the public under our Portfolio
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1 The following portfolio data for the Franklin Templeton funds is made available to the public under our Portfolio Holdings Release Policy and is "as of" the date indicated. This portfolio data should not be relied upon as a complete listing of a fund's holdings (or of a fund's top holdings) as information on particular holdings may be withheld if it is in the fund's interest to do so. Additionally, foreign currency forwards are not included in the portfolio data. Instead, the net market value of all currency forward contracts is included in cash and other net assets of the fund. Further, portfolio holdings data of over-the-counter derivative investments such as Credit Default Swaps, Interest Swaps or other Swap contracts list only the name of counterparty to the derivative contract, not the details of the derivative. Complete portfolio data can be found in the semi- and annual financial statements of the fund. Name H108 DDD U L101 M2239P Q W U201 BRGMH B P J100 DDD Y407 BYYT6W V G101 DDD ACADIA PHARMACEUTICALS INC 275,600 $9,825, % N/A N/A ACCELERON PHARMA INC 186,700 $9,103, % N/A N/A ACERTA PHARMA BV 1,192,774 $29,561, % N/A 02/01/49 ACLARIS THERAPEUTICS INC 333,500 $8,984, % N/A N/A ADMA BIOLOGICS INC 101,500 $823, % N/A N/A ADURO BIOTECH INC 227,573 $6,403, % N/A N/A ALCOBRA LTD 1,072,966 $6,738, % N/A N/A ALEXION PHARMACEUTICALS INC 213,500 $40,725, % N/A N/A ALNYLAM PHARMACEUTICALS INC 224,900 $21,172, % N/A N/A AMGEN INC 540,800 $87,788, % N/A N/A AMICUS THERAPEUTICS INC 736,100 $7,140, % N/A N/A ANACOR PHARMACEUTICALS INC 335,000 $37,844, % N/A N/A ANTHERA PHARMACEUTICALS INC 1,020,762 $4,736, % N/A N/A APTOSE BIOSCIENCES INC 488,883 $1,272, % N/A N/A AQUINOX PHARMACEUTICALS INC 436,900 $5,452, % N/A N/A ARATANA THERAPEUTICS INC 546,000 $3,046, % N/A N/A ARBUTUS BIOPHARMA CORP 496,755 $2,210, % N/A N/A ARCA BIOPHARMA INC 1,338,619 $145, % N/A 06/16/22 ARCA BIOPHARMA INC 478,077 $2,223, % N/A N/A AXOVANT SCIENCES LTD 450,882 $8,129, % N/A N/A BELLICUM PHARMACEUTICALS INC 257,000 $5,209, % N/A N/A BIOCRYST PHARMACEUTICALS INC 630,452 $6,506, % N/A N/A BIOGEN INC 356,761 $109,293, % N/A N/A BIOMARIN PHARMACEUTICAL INC 410,256 $42,978, % N/A N/A BIOPHARMX CORP 1,600,000 $2,196, % N/A N/A Page 1 of 5
2 Name 09074D G BV9FQJ U BWFKZT L Y F L DDD B P Q A105 BQRB1Q Q102 B94RPL H K102 DDD C3 BIOTIE THERAPIES OYJ 79,540 $1,125, % N/A N/A BLUEBIRD BIO INC 189,528 $12,171, % N/A N/A CARA THERAPEUTICS INC 202,400 $3,412, % N/A N/A CARBYLAN THERAPEUTICS INC 566,050 $2,049, % N/A N/A CATALYST PHARMACEUTICALS INC 841,915 $2,062, % N/A N/A CELGENE CORP 1,271,000 $152,214, % N/A N/A CELLDEX THERAPEUTICS INC 1,580,429 $24,781, % N/A N/A CELLECTIS 97,200 $3,016, % N/A N/A CHEMOCENTRYX INC 697,408 $5,649, % N/A N/A CONCERT PHARMACEUTICALS INC 263,800 $5,004, % N/A N/A CYNAPSUS THERAPEUTICS INC 565,300 $8,728, % N/A N/A CYTOMX THERAPEUTICS INC 118,700 $2,477, % N/A N/A CYTRX CORP 589,000 $1,560, % N/A N/A DERMA SCIENCES INC 993,789 $4,541, % N/A N/A DERMIRA INC 239,000 $8,271, % N/A N/A DYNAVAX TECHNOLOGIES CORP 307,670 $7,433, % N/A N/A EDGE THERAPEUTICS INC 184,900 $2,311, % N/A N/A EDGE THERAPEUTICS INC 517,946 $5,826, % N/A N/A EGALET CORP 863,400 $9,514, % N/A N/A ELEVEN BIOTHERAPEUTICS INC 880,697 $2,650, % N/A N/A FATE THERAPEUTICS INC 195,700 $659, % N/A N/A FIBROGEN INC 217,608 $6,630, % N/A N/A FLEX PHARMA INC 138,600 $1,725, % N/A N/A FOAMIX PHARMACEUTICALS LTD 413,800 $3,355, % N/A N/A GENOCEA BIOSCIENCES INC 790,900 $4,168, % N/A N/A GILEAD SCIENCES INC 1,431,000 $144,802, % N/A N/A GLYCOMIMETICS INC 379,800 $2,172, % N/A N/A GW PHARMACEUTICALS PLC 43,967 $3,053, % N/A N/A HALOZYME THERAPEUTICS INC 426,600 $7,392, % N/A N/A HEAT BIOLOGICS INC 624,200 $1,523, % N/A N/A HERON THERAPEUTICS INC 278,594 $6,435, % N/A 07/01/16 HERON THERAPEUTICS INC 1,486,710 $39,695, % N/A N/A IFT MONEY MARKET PORTFOLIO 26,436,621 $26,436, % N/A N/A Page 2 of 5
3 Name L H C V102 DDD X B4Q5ZN U L T R Q N T J103 BZ0GB Q9S3 DDD L C J109 DDD B948Z96 ILLUMINA INC 218,300 $41,901, % N/A N/A IMMUNE DESIGN CORP 303,100 $6,086, % N/A N/A IMMUNOGEN INC 371,300 $5,038, % N/A N/A INCYTE CORP 565,100 $61,285, % N/A N/A INOTEK PHARMACEUTICALS CORP 571,500 $6,475, % N/A N/A INTARCIA THERAPEUTICS INC 80,195 $2,870, % N/A N/A INTRA-CELLULAR THERAPIES INC 170,200 $9,155, % N/A N/A IONIS PHARMACEUTICALS INC 235,500 $14,584, % N/A N/A JAZZ PHARMACEUTICALS PLC 111,300 $15,644, % N/A N/A KARYOPHARM THERAPEUTICS INC 912,054 $12,084, % N/A N/A KITE PHARMA INC 115,344 $7,107, % N/A N/A KURA ONCOLOGY INC 378,400 $3,178, % N/A N/A LA JOLLA PHARMACEUTICAL CO 364,300 $9,836, % N/A N/A LION BIOTECHNOLOGIES INC 830,700 $6,413, % N/A N/A MACROGENICS INC 223,000 $6,906, % N/A N/A MARINUS PHARMACEUTICALS INC 729,600 $5,574, % N/A N/A MAST THERAPEUTICS INC 3,624,600 $217, % N/A 06/14/18 MAST THERAPEUTICS INC 1,750,620 $735, % N/A N/A MEDICINES CO 405,700 $15,148, % N/A N/A MEDIVATION INC 736,008 $35,578, % N/A N/A MIRATI THERAPEUTICS INC 236,350 $7,468, % N/A N/A MIRNA THERAPEUTICS INC 566,838 $3,542, % N/A N/A NABRIVA THERAPEUTICS AG 140,100 $1,337, % N/A N/A NANTKWEST INC 57,500 $896, % N/A N/A NANTKWEST INC 409,274 $6,383, % N/A N/A NATERA INC 474,962 $5,129, % N/A N/A NEOS THERAPEUTICS INC 256,400 $3,671, % N/A N/A NEUROCRINE BIOSCIENCES INC 453,500 $25,654, % N/A N/A NEWLINK GENETICS CORP 205,300 $7,470, % N/A N/A NIVALIS THERAPEUTICS INC 182,500 $1,412, % N/A N/A NORTHWEST BIOTHERAPEUTICS INC 223,880 $503, % N/A 02/20/19 NOVAVAX INC 1,179,900 $9,899, % N/A N/A NUVO RESEARCH INC 5,984 $22, % N/A N/A Page 3 of 5
4 Name DDD X Q L101 BQRX1W J V F B J108 B687XN K104 B39JBM F C N107 DDD DDD J X F100 NUVO RESEARCH INC 52,941 $199, % N/A N/A ONCOMED PHARMACEUTICALS INC 110,900 $2,499, % N/A N/A ONCOTHYREON INC 2,746,700 $6,097, % N/A N/A OPHTHOTECH CORP 106,132 $8,334, % N/A N/A OREXIGEN THERAPEUTICS INC 1,669,123 $2,870, % N/A N/A OVASCIENCE INC 250,154 $2,444, % N/A N/A PFENEX INC 532,384 $6,590, % N/A N/A PORTOLA PHARMACEUTICALS INC 327,800 $16,865, % N/A N/A PRONAI THERAPEUTICS INC 100,000 $1,504, % N/A N/A PROQR THERAPEUTICS NV 123,300 $1,070, % N/A N/A PTC THERAPEUTICS INC 160,000 $5,184, % N/A N/A PUMA BIOTECHNOLOGY INC 110,644 $8,674, % N/A N/A RADIUS HEALTH INC 143,600 $8,837, % N/A N/A REGENERON PHARMACEUTICALS INC 113,209 $61,457, % N/A N/A REGENXBIO INC 25,200 $418, % N/A N/A RELYPSA INC 301,000 $8,530, % N/A N/A RETROPHIN INC 576,494 $11,120, % N/A N/A REVANCE THERAPEUTICS INC 248,800 $8,499, % N/A N/A SAGE THERAPEUTICS INC 339,370 $19,785, % N/A N/A SAGENT PHARMACEUTICALS INC 620,357 $9,869, % N/A N/A SCICLONE PHARMACEUTICAL INC 1,727,919 $15,896, % N/A N/A SHIRE PLC 151,700 $31,098, % N/A N/A SORRENTO THERAPEUTICS INC 132,951 $1,158, % N/A N/A STEMLINE THERAPEUTICS INC 606,400 $3,826, % N/A N/A SYNERGY PHARMACEUTICALS INC 814,567 $4,618, % N/A N/A TESARO INC 191,500 $10,019, % N/A N/A THERAPEUTICSMD INC 2,417,940 $25,074, % N/A N/A THRESHOLD PHARMACEUTICALS INC 439,500 $0 0.00% N/A 02/12/20 THRESHOLD PHARMACEUTICALS INC 190,476 $0 0.00% N/A 03/16/16 TOKAI PHARMACEUTICALS INC 183,000 $1,595, % N/A N/A TONIX PHARMACEUTICALS HOLDING 147,281 $1,129, % N/A N/A TRILLIUM THERAPEUTICS INC 158,100 $1,993, % N/A N/A VERTEX PHARMACEUTICALS INC 324,500 $40,831, % N/A N/A Page 4 of 5
5 Name F E L204 VTV THERAPEUTICS INC 370,900 $2,525, % N/A N/A XENCOR INC 339,701 $4,966, % N/A N/A ZAFGEN INC 554,026 $3,484, % N/A N/A ZOGENIX INC 246,315 $3,630, % N/A N/A Important Legal Information Portfolio holdings are subject to change without notice and may not represent current or future portfolio composition. The portfolio data is as of the date indicated and we disclaim any responsibility to update the information. The net market value of all currency forward contracts is included in cash and other net assets, reflected in the base currency of the fund. The net market value of any Credit Default, Interest and/or other Swap contract positions are displayed as exposure to the issuing counterparty (i.e. "Citibank"). Unlike the fund s regulatory filings, the portfolio data and its presentation in this document are not required to conform to Generally Accepted Accounting Principles (GAAP) and Securities and Exchange Commission (SEC) presentation requirements. Therefore, it differs from that in the complete statement of investments in the annual and semiannual report to shareholders filed with the SEC on Form N-CSR, and the complete statement of investments provided in the first and third quarter SEC Form N-Q filings for each fiscal year. The portfolio data is for information only. It does not constitute a recommendation or an offer for a particular security or fund, nor should it be taken as a solicitation or a recommendation to buy or sell securities or other investments. Investors should carefully consider a fund's investment goals, risks, charges and expenses before investing. To obtain a prospectus, which contains this and other information, talk to your financial advisor, call us at 1-800/DIAL BEN (1-800/ ) or visit our website at franklintempleton.com. Please read the prospectus carefully before investing. Franklin Templeton Distributors Inc., One Franklin Parkway, San Mateo, CA Copyright Franklin Templeton Investments. All rights reserved. Page 5 of 5
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