i) Research Papers in peer-reviewed journals

Transcription

1 Dr Kicman Publications List: Currently 46 Research Papers Published in Journals, with another 3 Papers in Submission/Press, 14 Reviews published in Journals/Books and 5 Extended Proceedings. i) Research Papers in peer-reviewed journals 2011 Turfus SC, Braithwaite RA Parkin MC, Cowan DA, Smith NW, Kicman AT. Metabolites of Lorazepam; Relevance of Past Findings to Present Day Use of LC-MS/MS in Analytical Toxicology. Drug Test Anal (current submission) Bell C, George C, Kicman AT, Traynor AD. Development of a rapid LC- MS/MS method for direct urinalysis of designer drugs. Drug Test Anal (current submission) Gavrilovic I, Mitchell K, Brailsford AD, Cowan DA, Kicman AT, Ansell RJ. A molecularly imprinted receptor for separation of testosterone and epitestosterone, based on a steroidal cross-linker. Steroids (in press) Brailsford AD, Cowan DA, Kicman AT. Urinary gamma-hydroxybutyrate concentrations in 1126 female subjects. J Anal Toxicol 2010; 34: Goucher E, Kicman A, Wolff K, Smith N, Jickells S. Hydrophilic stationary phases: A practical approach for the co-analysis of compounds with varying polarity in biological matrices. Journal of Separation Science 2010; 33: Turfus SC, Parkin MC, Cowan DA, Halket JM, Smith NW, Braithwaite RA, Elliot SP, Steventon GB, Kicman AT. Use of human microsomes and deuterated substrates; An alternative approach for the identification of novel metabolites of ketamine by mass spectrometry. Drug Metabolism and Disposition 2009;37: Goucher E, Kicman AT, Smith NW, Jickells S. The detection and quantification of lorazepam and its 3-O-glucuronide in fingerprint deposits by LC-MS/MS. Journal of Separation Science 2009, 32, Graham M, Ryan P, Baker JS, Davies B,Thomas NE, Cooper SM, Evans P, Easmon S,.Walker CJ, Cowan DA, Kicman AT. Counterfeiting in performance- and image-enhancing drugs. Drug Testing and Analysis 2009, 1, Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT). Doping in sport-1. Excretion of 19-norandrosterone by healthy women, including those using contraceptives containing norethisterone. Steroids, 2009;74: Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT Doping in sport-2. Quantification of the impurity 19-norandrostenedione in pharmaceutical preparations of norethisterone. Steroids, 2009;74:

2 Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT. Doping in sport: 3. Metabolic conversion of oral norethisterone to urinary 19-norandrosterone. Steroids, 2009;74: Parkin MC, Turfus SC, Smith NW, Halket JH, Braithwaite RA, Elliott SP, Cowan DA, Kicman AT. (2008) Detection of ketamine and its metabolites in urine by ultra high pressure liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2008;876: Cowan DA, Kicman AT, Kubli-Garfias C, Welchman HJ. Ion trap MS/MS of intact testosterone and epitestosterone conjugates--adducts, fragile ions and the advantages of derivatisation. Steroids 2008;73: Graham MR, Baker JS, Evans P, Kicman A, Cowan D, Hullin D, et al. Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency. Hormone Research 2008;69: Graham MR, Davies B, Kicman A, Cowan D, Hullin D, Baker JS. Recombinant human growth hormone in abstinent androgenic-anabolic steroid use: psychological, endocrine and trophic factor effects. Current Neurovascular Research 2007;4:9-18. Graham MR, Baker JS, Evans P, Kicman A, Cowan D, Hullin D, Davies B. Evidence for a decrease in cardiovascular risk factors following recombinant growth hormone administration in abstinent anabolic-androgenic steroid users. Growth Horm IGF Res 2007;17: Graham MR, Baker JS, Evans P, Kicman A, Cowan D, Hullin D, Davies B. Short-term recombinant human growth hormone administration improves respiratory function in abstinent anabolic-androgenic steroid users. Growth Horm IGF Res 2007;17: Walton MJ, Anderson RA, Kicman AT, Elton RA, Ossowska K, Baird DT. A diurnal variation in testicular hormone production is maintained following gonadotrophin suppression in normal men. Clin Endocrinol 2007;66: Graham MR, Grace FM, Boobier W, Hullin D, Kicman A, Cowan D, et al. Homocysteine induced cardiovascular events: a consequence of long term anabolic-androgenic steroid (AAS) abuse. British Journal of Sports Medicine 2006;40: Cawood ML, Field HP, Ford CG, Gillingwater S, Kicman AT, Cowan D, Barth JH. Testosterone measurements by isotope-dilution liquid chromatography-tandem mass spectrometry: validation of a method for routine clinical practise. Clin Chem 2005;51:

3 Malatos S, Neubert H, Kicman AT, Iles RK. Identification of placental transforming growth factor beta and bikunin metabolites as contaminants of pharmaceutical human chrorionic gondadotrophin preparations by proteomic techniques. Mol Cell Proteomics 2005;4: Bassindale T, Cowan DA, Dale S, Leeds AR, Hutt AJ, Wheeler MJ, Kicman AT. Effects of oral administration of androstenedione on plasma androgens in young women using hormonal contraception. J Clin Endo Metab 2004;89: Brady BM. Walton M, Hollow N, Kicman AT, Baird DT, Anderson RA. Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception. Hum Reprod 2004;19: Jacoby ES, Kicman AT, Iles RK. Identification of post-translational modifications resulting from LHbeta polymorphisms by matrix-assisted laser desorption time-of-flight mass spectrometric analysis of pituitary LHbeta core fragment. J Mol Endocrinol 2003;30: Kicman AT, Bassindale T, Cowan DA, Dale S, Hutt AJ, Leeds AR. Effect of androstenedione ingestion on plasma testosterone in young women; a dietary supplement with potential health risks. Clin Chem 2003;49:167-9 (technical brief) Kicman AT, Fallon JK, Cowan DA, Walker C, Easmon S, Mackintosh D. Candida albicans in urine can produce testosterone: impact on the testosterone/epitestosterone sports drug test. Clin Chem 2002;48: (technical brief). Kinniburgh D, Zhu H, Cheng L, Kicman AT, Baird DT, Anderson RA. Oral desogestrel with testosterone pellets induces consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men. Hum Reprod 2002;17: Forsling ML, Fallon JK, Shah D, Tilbrook GS, Cowan DA, Kicman AT, et al. The effect of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and its metabolites on neurohypophysial hormone release from the isolated rat hypothalamus. Br J Pharmacol 2002;135: Fallon JK, Shah D, Kicman AT, Hutt AJ, Henry JA, Cowan DA, et al. Action of MDMA (ecstasy) and its metabolites on arginine vasopressin release. Ann N Y Acad Sci 2002;965: Neubert H, Kicman AT, Cowan DA, Bansal SS. Synthesis of a dendron and dendrimer consisting of MALDI matrix like branching units. Tetrahedron Letters 2002;43:

4 Neubert H, Jacoby ES, Bansal SS, Iles RK, Cowan DA, Kicman AT. Enhanced affinity capture MALDI-TOF MS: Orientation of an immunoglobulin G using recombinant protein G. Anal Chem 2002;74: Forsling M, Fallon JK, Kicman AT, Hutt AJ, Cowan DA, Henry JA. Arginine vasopressin release in response to the administration of 3,4- methylenedioxymethamphetamine ("ecstasy"): is metabolism a contributory factor? J Pharm Pharmacol 2001;53: Jacoby ES, Kicman AT, Laidler P, Iles RK. Determination of the glycoforms of human chorionic gonadotropin beta-core fragment by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Clin Chem 2000;46: Kicman AT, Coutts SB, Cowan DA, Handelsman DJ, Howe CJ, Burring S, et al. Adrenal and gonadal contributions to urinary excretion and plasma concentration of epitestosterone in men--effect of adrenal stimulation and implications for detection of testosterone abuse. Clin Endocrinol (Oxf) 1999;50: Fallon JK, Kicman AT, Henry JA, Milligan PJ, Cowan DA, Hutt AJ. Stereospecific analysis and enantiomeric disposition of 3,4- methylenedioxymethamphetamine (Ecstasy) in humans. Clin Chem 1999;45: Butler SA, Laidler P, Porter JR, Kicman AT, Chard T, Cowan DA, et al. The beta-subunit of human chorionic gonadotrophin exists as a homodimer. J Mol Endocrinol 1999;22: Henry JA, Fallon JK, Kicman AT, Hutt AJ, Cowan DA, Forsling M. Lowdose MDMA ("ecstasy") induces vasopressin secretion [research letter]. Lancet 1998;351:1784. Laidler P, Cowan DA, Houghton E, Kicman AT, Marshall DE. Discrimination of mammalian growth hormones by peptide-mass mapping. Rapid Commun Mass Spectrom 1998;12: Kicman AT, Miell JP, Teale JD, Powrie J, Wood PJ, Laidler P, et al. Serum IGF-I and IGF binding proteins 2 and 3 as potential markers of doping with human GH. Clin Endocrinol (Oxf) 1997;47: Wheeler MJ, Zhong YB, Kicman AT, Coutts SB. The measurement of testosterone in hair. J Endocrinol 1998;159:R5-8. 4

5 1997 Laidler P, Cowan DA, Hider RC, Kicman AT. Characterization of human chorionic gonadotropin microheterogeneity by capillary electrophoresis: potential application for quality control in the pharmaceutical industry. Pharmaceutical Sciences. 1997;3: Coutts, S. B., Kicman, A. T., Hurst, D. T. & Cowan, D. A. 1997, 'Intramuscular administration of 5 alpha-dihydrotestosterone heptanoate: changes in urinary hormone profile', Clin Chem, vol. 43, no. 11, pp Kicman AT, Coutts SB, Walker CJ, Cowan DA. Proposed confirmatory procedure for detecting 5 alpha- dihydrotestosterone doping in male athletes. Clin Chem 1995;41: Laidler P, Cowan DA, Hider RC, Keane A, Kicman AT. Tryptic mapping of human chorionic gonadotropin by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 1995;9: Kicman AT, Cowan DA, Myhre L, Nilsson S, Tomten S, Oftebro H. Effect on sports drug tests of ingesting meat from steroid (methenolone)-treated livestock. Clin Chem 1994;40: Laidler P, Cowan DA, Hider RC, Kicman AT. New decision limits and quality-control material for detecting human chorionic gonadotropin misuse in sports. Clin Chem 1994;40: Kicman AT, Oftebro H, Walker C, Norman N, Cowan DA. Potential use of ketoconazole in a dynamic endocrine test to differentiate between biological outliers and testosterone use by athletes. Clin Chem 1993;39: Southan GJ, Brooks RV, Cowan DA, Kicman AT, Unnadkat N, Walker CJ. Possible indices for the detection of the administration of dihydrotestosterone to athletes. J Steroid Biochem Mol Biol 1992;42: Kicman AT, Brooks RV, Collyer SC, Cowan DA, Nanjee MN, Southan GJ, et al. Criteria to indicate testosterone administration. Br J Sports Med 1990;24:

6 ii) Reviews: Cole C, Jones L, McVeigh J, Kicman A, Syed Q, Bellis M. Adulterants in illicit drugs: a review of empirical evidence. Drug Test Anal 2011;3: All of the below were invited reviews Kicman AT. Biochemical and Physiological Aspects of Endogenous Androgens. Handbook of Experimental Pharmacology. 2010; 195:25-64 Kicman AT, Houghton E, Gower DB. Anabolic steroids: Metabolism, doping and detection in human and equestrian sports.. Steroid Analysis (2 nd Edition). Springer, 2010 Analysis of Corticosteroids. Steroid Analysis (2 nd Edition). Fraser R, Gower DB, Honour JW, Ingram MC, Kicman AT, Makin HLJ, Stewart, PM. Springer 2010 Kicman AT, Cowan DA. Subject-based Profiling for the Detection of Testosterone Administration in Sport. Drug Testing and Analysis. 2009; 1: Kicman AT. Pharmacology of anabolic steroids. British Journal of Pharmacology 2008;154: Graham MR, Davies B, Grace FM, Kicman A, Baker JS. Anabolic steroid use: patterns of use and detection of doping. Sports medicine (Auckland, NZ 2008;38: Kicman AT, Parkin MC, Iles RK. An introduction to mass spectrometry based proteomics - Detection and characterization of gonadotropins and related molecules. Molecular and Cellular Endocrinology 2007;260: James VHT, Kicman AT (first draft authors). Medical aspects of drug use in the gym. Drug Therap Bull. 2004;42:1-5. Kicman AT, Gower DB. Anabolic steroids in sport: biochemical, clinical and analytical perspectives. Ann Clin Biochem 2003;40: Gower DB, Houghton E, Kicman AT. Anabolic steroids:metabolism, doping and detection. In: Makin HLJ, Gower DB, Kirk DN, eds. Steroid analysis. First edition. ed. Glasgow: Blackie Academic and Professional (imprint of Chapman & Hall), 1995: Cowan DA, Kicman AT. Doping with Peptide Hormones. In: Hemmersbach P, Birkeland KI. Blood samples in doping control. Pensumtjeneste (On Demand Publishing). 1994: Kicman AT, Brooks RV, Cowan DA. Human chorionic gonadotrophin and sport. Br J Sports Med 1991;25: Kicman AT, Cowan DA. Peptide hormones and sport: misuse and detection. Br Med Bull 1992;48:

7 iii) Examples of Extended Proceedings: Gavrilovic I, Ansell RJ, Brailsford AD, Cowan DA, Kicman AT, Molecularly imprinted polymers selective for testosterone; potential application for GC/C/IRMS sample clean-up. Proceedings of the Manfred Donike Workshop. Koln: Sport und Buch Strauss, Walker CJ, Cowan DA, Taylor NF, Kicman AT. Determination of xenobiotic glucocorticoids by gas chromatography-mass spectrometry. In: Schanzer W, Geyer H, Gotzmann A, Mareck U, eds. Recent Advances in Doping Analysis (14) - Proceedings of the Manfred Donike Workshop. Koln: Sport und Buch Strauss, 2006; Bassindale T, Cowan DA, Dale S, Hutt AJ, Leeds AR, Kicman AT. Disposition of androstenedione and testosterone following oral administration of androstenedione to healthy female volunteers; influence on the urinary T/E profile. In: Schanzer W, Geyer H, Gotzmann A, Mareck U, eds. Recent Advances in Doping Analysis (10) - Proceedings of the Manfred Donike Workshop. Koln: Sport und Buch Strauss, 2002; Approaches to the analysis of protein hormones. Discrimination of mammalian growth hormones by peptide-mass mapping. Proceedings of the 12th International Conference of Racing Analysts and Veterinarians. 2000; pp Laidler P, Cowan DA, Hider RC, Kicman AT. Qualitative analysis of hcg for confirmatory purposes. In: Schanzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Recent Advances in Doping Analysis (4) - Proceedings of the Manfred Donike Workshop. Koln: Sport und Buch Strauss, 1997: