RECENT ADVANCES IN DOPING ANALYSIS

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1 w. SCHANZER H. GEYER A. GOTZMANN U. MARECK-ENGELKE (EDITORS) RECENT ADVANCES IN DOPING ANALYSIS (7) Proceedings of the Manfred Donike Workshop 17th Cologne Workshop on Dope Analysis 14th to 19th March 1999 SPORT und BUCH StrauG Koln 1999

2 TABLE OF CONTENT I NEW ASPECTS IN DOPING ANALYSIS PAGE R K MUELLER, J. GROSSE, D. THIEME, R. PREISS: 13 Banned Agents and Related Compounds - How many? J.-C. MATHURIN, J. DE CEAURRIZ, M.-T. SICART, B. MARION, M. AUDRAN, 21 M.-P. KRAFFT: Development of an Analytical Strategy for Detection of Perfluorocarbons (PFCs) for Anti-Doping Control: Analysis of Breath and Blood Samples after i.v. Injection of a PFCs Emulsion in Rats M. THEVIS, G. OPFERMANN, W. SCHANZER: 31 GC/MS-Detection of Hydroxyethyl Starch (HES) in Human Urine D. DEBOER, L J A.L.DOSREYS, I.J. BOSMAN, R.A.A. MAES: 41 The Detection of the Use of some Popular Hallucinogenic Compounds, including those of Psilocybe Mushrooms U. MARECK-ENGELKE, H. GEYER, W. SCHANZER: 51 Tetrahydrocannabinol (THC) in Dope Control D. GOUDREAULT, A. FAKIRIAN: 61 Selegiline Urinary Metabolites H. GEYER, E. NOLTEERNSTING, W. SCHANZER: 71 Finasteride - A Substance for Manipulation in Dope Control? R S BLACK, L. D BOWERS: 81 A Potential Case of Fluvoxamine-Induced Inhibition of Caffeine Metabolism B. YAP, R. KAZLAUSKAS: 85 Corticosteroids and Exercise-Stress Response II ANABOLIC AGENTS M. SAUGY, N. ROBINSON, C. CARDIS, C. SCHWEIZER, L. RIVIER, P. MANGIN, 95 C. AYOTTE, J. DVORAK: Nandrolone Metabolites in Football Players: Utility for in and out of Competition Tests B. LE BIZEC, I. GAUDIN, A. POHU, F. MONTEAU, F. ANDRE: 109 Identification of Endogenous 19-Norandrosterone in Human Urine

3 V.P. URALETS, P.A. GILLETTE: 121 Over-the-Counter A 5 Anabolic Steroids 5-Androsten-3,17-dione; 5-Androsten-3p,17(3- diol, Dehydroepiandrosterone and 19-Nor-5-androsten-3,17-dione: Excretion Studies in Men R.K. MUELLER, R. PREISS, M. KRUEGER: 131 Anabolic Steroids and Enhanced Aggressiveness J. GROSSE, D. THIEME, R. LANG, R.K. MUELLER: 143 Formebolone Detection B. VITORIANO, D. DE BOER, C. MANZONI, A. AJENJO, L.J.A.L.DOS REYS: 153 Preliminary Results of the Implementation of some Metabolites of the Anabolic Androgenic Testolactone in the Screening Procedures D.H. VAN DE KERKHOF, P.M. VAN DER VOORT, D. DE BOER, R. A. A. MAES: 161 Confirmation of Endogenous Boldenone Production: A Procedure for an in vitro Experiment J.-F. LEVESQUE, CH. AYOTTE: 169 Criteria for the Detection of Androstenedione Oral Administration S. WESTWOOD, B. NOBLE, C. MOULE: 181 Synthesis and Characterisation of Steroid Metabolites for Use as Analytical Reference Materials R BERGES, J SEGURA, K.D. FITCH, A.R. MORTON, X. DE LA TORRE, R. VENTURA, 193 M. MAS, M. FARRE: Discrimination of Prohibited Oral Use of Salbutamol in Sport from Authorized Inhaled Asthma Treatment: Update P.J. VANDERMERWE: 203 The Influence of the Use of Multiple Doses of DHEA on the Steroid Profile J.F. LEVESQUE, C. AYOTTE: 213 The Oral Administration of DHEA : The Efficiency of Steroid Profiling III TECHNIQUES OF MS DETECTION AND SAMPLE PREPARATION J. ROGERSON, G.J. TROUT: 223 GC-C-IRMS Detection of Steroid Metabolites - Some Hardware Considerations M. BECCHI, F PERRET, D. FOREST, J C. MATHURIN, J. DE CEAURRIZ: 233 Carbone Isotope Ratio Mass Spectrometry of Endogenous Corticosteroids

4 U. FLENKER, E. NOLTEERNSTING, H. GEYER, W. SCHANZER: 241 A Screening Method for Synthetic Testosterone and its Precursors based on GC/C/IRMS G. TROUT, S. SOO, R. KAZLAUSKAS: 249 A Single Screen for Steroids using HRMS T. KUSAMRAN, X. DE LA TORRE, R. DE LA TORRE, B. RASMUSSEN, P. WlLAIRAT, 255 T. ANUKARAHANONTA: Monitoring of Low Concentration Anabolic Steroids in Urine Samples from the 13 th Asian Games by Ion-trap GC/MS/MS M. Wu, Y. ZHANG, X. Liu, C. ZHANG: 267 CID Mass Spectrometric Characterization of some Epimeric Anabolic Androgenic Steroids R. KAZLAUSKAS, T. HUYNH, A. STENHOUSE, S. SOO, J. TJOA, B. YAP: 281 Automated Solid Phase Extraction IV PEPTIDE HORMONES K.I. BIRKELAND, K. FlSKUM, B. BJERKE, E. HAUG, P. HEMMERSBACH: 289 Physiological and non-physiological Variations in Serum Levels of Soluble Transferrin Receptor - Implications for Use as Indicator of Doping with rhepo K.R. EMSLIE, C. HOWE, G. TROUT: 291 Measurement of Urinary Erythropoietin Levels in Athletes B. BlALAS, A. BREIDBACH, W. SCHANZER: 301 Individual Reference Ranges for Serum Erythropoietin (sepo) - Part II: Influence of Long Distance Flying V POSTER PRESENTATION X. Liu, Y. ZHANG, M. WU, C. ZHANG: 311 The Steroid Profiles after Oral Administration of Testosterone Undecanoate with Different Doses MAS. MARQUES, C.H.B. BIZARRI, J. N. CARDOSO, F R DE AQUINO NETO 317 Effect of Finasteride on the Urinary Steroid Profile: A Case Study

5 T KUURANNE, M. VAHERMO, A. LEINONEN, K. KUOPPASALMI, J. TASKINEN, 323 E. El.OVAARA, R. KOSTIAINEN: ESI-MS and MS/MS Detection of the Glucuronide Conjugate of 17o-methyl-5p-androstan-3a,17P-diol and its Da-labelled Analogue R. ARMSTRONG, S. BIDDLE, E. HOUGHTON: 329 Highly Specific, Low Level Detection of Stanozolol and Metabolites using Solid Phase Extraction and ELISA Technology M.K. HENZE, G. OPFERMANN, W. SCHANZER: 335 Liquid-Liquid Extraction-pH-Profiles of Selected Beta-2-Sympathomimetic Agonists E HABER, J. MUNOZ-GUERRA, C. SORIANO, D. CARRERAS, C. RODRIGUEZ, 341 FA. RODRIGUEZ: Automated Preparation for Screening of Anabolic Steroids in Urine in HP 7686 PrepStation System R GRUCZA, J. SMORAWINSKI, D KWIATKOWSKA: 347 Application of Ketoconazole Test in Doubtful Doping Cases of Polish Athletes I. SEINSCH, C.V. KUK, M. MACHNIK, G. SEBIG, S. HORNING, G. SIGMUND, 353 A BREIDBACH, W. SCHANZER Detection of Nortestosterone Application in Horses. A Screening Method for Nortestosterone in Horse Serum with a Possible Confirmation in Urine V. CKIMELE, P. KINTZ, A. TRACQUI, B. LUDES: 359 Identification of 10 Corticosteroids in Human Hair by Liquid Chromatography Ionspray Mass Spectrometry A KNIEB, R.K. MOLLER, J. KRATZSCH. 365 Quantitation of Human Growth Hormone, Insulin-like Growth Factors I and II (IGF-I and II) and IGF Binding Protein-2 and -3 in Athletes [,,Blood Study" of the German Antidoping Commission (ADK)] H BAEZ-G, C CAMARGO-G.: 371 The Occurrence of Cocaine and Metabolites in Hair of Drug Abusers Possible Determination of Cut-Off Values Xu YOUXUAN, PENG SHIQI, QIN YANG, YANG SHUMIN: 377 Determination of Urinary Clopamide by Using LC/APCI/MS A POKRYWKA, D KWIATKOWSKA, D STANCZYK, K. CHROSTOWSKI: 383 Midodrine (Gutron) Detection in Urine Samples. Should Midodrine be Added to the IOC Doping List?

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