RECENT ADVANCES IN DOPING ANALYSIS (8)

Transcription

1 w. SCHANZER H. GEYER A. GOTZMANN U. MARECK-ENGELKE (EDITORS) RECENT ADVANCES IN DOPING ANALYSIS (8) Proceedings of the Manfred Donike Workshop 18th Cologne Workshop on Dope Analysis 20th to 25th February 2000 SPORT und BUCH StrauB Koln 2000

2 TABLE OF CONTENT I NUTRITIONAL SUPPLEMENTS PAGE P.VAN EENOO, F.T.DELBEKE, N.DESMET, P.DE BACKER: 13 Excretion Studies with Tribulus Terrestris H.GEYER, U.MARECK-ENGELKE, W.SCHANZER: 23 The Analysis of Nutritional Supplements for Anabolic - Androgenic Steroids A.GOTZMANN, B.KOMANNS, A.ADIB, M.BREDEHOFT, W.SCHANZER: 33 Creatine - A Doping Substance? II NEW ASPECTS IN DOPING ANALYSIS M.THEVIS, G.OPFERMANN, W.SCHANZER: 41 Rapid Screening Method to Detect Hydroxyethyl Starch (HES) in Human Urine D.THIEME, J.GROSSE, R.LANG, R.K.MUELLER, A.WAHL: 47 Suitability of HPLC/MS-MS for the Detection of Diuretics L.DAMASCENO, R.VENTURA, J.ORTUNO, M.FARRE, J.CARDOSO, J.SEGURA, 57 C.JIMENEZ: Analytical Methodology for the Detection of (3,-agonists in Urine by GC/MS M.K.HENZE, G.OPFERMANN, H.SPAHN-LANGGUTH, W.SCHANZER: 59 Screening of Beta-2-Agonists and Confirmation of Fenoterol, Reproterol, Orciprenaline and Terbutaline after Cyclisation with Formaldehyde U.FLENKER, V.GOUGOULIDIS, W.SCHANZER: 69 Confirmation of Doping with Synthetic Endogenous Anabolic Steroids: Validation of the Method and Concepts of Inference N.ROBINSON, B. MARTI, P. MANGIN, M.SAUGY: 79 Secondary Markers of Erythroid Activity: Any Use for Doping Diagnosis in Professional Cyclists? M. ZORZOLI, L. SCHATTENBERG, P. MANGIN: 83 The Medical Monitoring of the International Cycling Union

3 Ill TOOLS FOR THE ANALYSIS OF ANABOLIC STEROIDS PAGE M.THEVIS, E.NOLTEERNSTING, G.OPFERMANN, W.SCHANZER: Synthesis and GC/MS-Characterization of Glucuronide Conjugates of Anabolic Steroids 89 T.K.UURANNE, A.LEINONEN, O.AlTIO, K.KUOPPASALMI, R.KOSTIAINEN: " Enzyme-assisted Synthesis and Mass Spectrometric Behaviour of Anabolic Steroid Glucuronides S.WESTWOOD, D.HANCOCK, C.MOULE, B.NOBLE, S.STARLING: Progress in the Preparation of Anabolic Steroid Reference Materials & Certified Reference Materials V.P.URALETS, P.A.GILETTE: Some Useful Applications of Helix Pomatia Juice in Anabolic Steroid Testing. Essential Metabolites of Sulfate Fraction. D.H.VAN DE KERKHOF, J.W.ZWIKJCER, V.E.M.KAATS-RICHTERS, K.BOUWMAN, R.D.VAN OOUEN, D.DE BOER, R.A.A.MAES: Trimethylsilylation of 3-Keto-A4-ene Steroids: Thermodynamic Versus Kinetic Control of Enolization I IV DETECTION OF 1 9-NORANDROSTERONE P.HEMMERSBACH, A.H.HAGENSEN, J.MISUND: Determination of Urinary Norandrosterone Excretion in Females during one Menstrual Cycle by Gas Chromatography / Mass Spectrometry U.MARECK-ENGELKE, G.SCHULTZE, H.GEYER, W.SCHANZER: 19-Norandrosterone in Pregnant Women W.SCHANZER, A.BREIDBACH, H.GEYER, C.V.KUK, E.NOLTEERNSTING, M.THEVIS: Metabolism of Nortestosterone, Norandrostenedione and Norandrostenediol: Identification of 3a-hydroxyestr-4-en-17-one glucuronide and 3a,16a-dihydroxy-5a-estran-l7-one glucuronide and sulphate

4 V POSTER PRESENTATION PAGE D.MlRSON, A.RlDOLFI, P.QUIROGA, G.PASCUALI, H.GONZALEZ, C.LOPEZ. 175 E.ViLLAAMiL, O.ROSES: Urinary Excretion of Cocaine, Ecgonine Methyl Ester and Benzoylecgonine Following Ingestion of Coca Leaves Decoction R.VENTURA, L.DAMASCENO, J.CARDOSO, J.SEGLRA: Confirmation P-Agonists in Urine by GCMS Using the Diagnostic Evidence of two Consecutive Derivatization Procedures 1 S3 N.HALATCHEVA, E.DANEVA: 189 Some Aspects of Investigation of Extraction, Denvatisation and Excretion of Terbutalme and Salbutamol D.KAROYA, M.ANGUELOVA. N.HALATCHEVA: 197 Amilonde - Detection and Excretion Study under Condition of Steroid Screening Procedure I.BAILLOUX, S.DE BARROS, A.LAHAUSSOIS, J.-C.MATHURIN. J.DE CEAL RRIZ: 203 LC-MS and LC-MS MS in Doping Control Analysis of Synthetic Glucocorticoids M.FERRY. J.-C.MATHURIN, M.BECCHI. J.DE CEAL RRIZ: Influence of Pregnenolone Administration on IRMS Analysis 2oy G.VAJIALA. R.MIHAILESCI. M.LAMOR: 215 Benzbromarone - A Possible Masking Agent of Androgen Anabolic Steroids: Identification by GC MS and its Action upon the Steroid Profile (11 C.D'ANGELO. L.MBARAK. G.CASES. E.CECX ARELI.I. L.CHINC HILI J,. 221 C.Di N'ARDO. L.IGLESIAS. C.OCHOA. O.TF.ME CENTURION. E.ZVDORK KI. G.CABAU ERO: Quantification of Epitestosterone and Testosterone in Urine by Gas Chromatography-Mass Spectrometry J.GROSSE. R.L^NG, R.K.MI ELLI-R, D.THIEME. A.WAHI : 22" Appearance of an Oxabolone Metabolite after Administration of OT( 19-\orstcroids - Metabolite or Artefact? C.RODRIGI E/. J.Mt NOZ-Gl ERRA. M.Pl AIA. C Fl RNANDI /. 233 A.K.RODRIdl D.CARRI.RAS: Statistical Analysis Relating to Detection of 19-Norandrostcrone in 1 "2S3 Samples analysed in the Doping Control Laboratory of Madrid during 1WS and 1999

5 PAGE C.RODRIGUEZ, J.MUNOZ-GUERRA, M.PLATA, C.FERNANDEZ, 239 A.F.RODRIGUEZ, D.CARRERAS: Antidoping Testing at the VIIIAAF World Championships in Athletics, August 1999 Sevilla (Spain) P.J.VAN DER MERWE, H.S.L.KRUGER, J.W.PLETERSE, M.J.PRETORIUS, 245 N.J.DEKOCK: Report on the Doping Control during the 7* All Africa Games in South Africa