Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces

Transcription

1 Supporting Information Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces Nan Ding,, Yi Jiang, Li Han, Xiu Chen, Jian Ma, Xiaodan Qu, Yu Mu, Jiang Liu, Liya Li, Chenglin Jiang, Xueshi Huang, Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang , P. R. China Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang , P. R. China Yunnan Institute of Microbiology, Yunnan University, Kunming , P. R. China *To whom correspondence should be addressed. Tel: Fax: i

2 Figure S1. HRESI-MS spectrum of the new compound 1 Figure S2. 1 H NMR (600 MHz, DMSO-d 6 ) spectrum of the new compound 1 Figure S3. 13 C NMR (150 MHz, DMSO-d 6 ) spectrum of the new compound 1 Figure S4. HSQC spectrum of the new compound 1 Figure S5. HMBC spectrum of the new compound 1 Figure S6. COSY spectrum of the new compound 1 Figure S7. NOESY spectrum of the new compound 1 Figure S8. HRESI-MS spectrum of the new compound 2 Figure S9. 1 H NMR (600 MHz, DMSO-d 6 ) spectrum of the new compound 2 Figure S C NMR (150 MHz, DMSO-d 6 ) spectrum of the new compound 2 Figure S11. HSQC spectrum of the new compound 2 Figure S12. HMBC spectrum of the new compound 2 Figure S13. COSY spectrum of the new compound 2 Figure S14. NOESY spectrum of the new compound 2 Figure S15. HRESI-MS spectrum of the new compound 3 Figure S16. 1 H NMR (600 MHz, DMSO-d 6 ) spectrum of the new compound 3 Figure S C NMR (150 MHz, DMSO-d 6 ) spectrum of the new compound 3 Figure S18. HSQC spectrum of the new compound 3 ii

3 Figure S19. HMBC spectrum of the new compound 3 Figure S20. COSY spectrum of the new compound 3 Figure S21. NOESY spectrum of the new compound 3 Figure S22. HRESI-MS spectrum of the new compound 10 Figure S23. 1 H NMR (600 MHz, DMSO-d 6 ) spectrum of the new compound 10 Figure S C NMR (150 MHz, DMSO-d 6 ) spectrum of the new compound 10 Figure S25. HSQC spectrum of the new compound 10 Figure S26. HMBC spectrum of the new compound 10 Figure S27. COSY spectrum of the new compound 10 Figure S28. NOESY spectrum of the new compound 10 Figure S29. HRESI-MS spectrum of the new compound 11 Figure S30. 1 H NMR (600 MHz, DMSO-d 6 ) spectrum of the new compound 11 Figure S C NMR (150 MHz, DMSO-d 6 ) spectrum of the new compound 11 Figure S32. HSQC spectrum of the new compound 11 Figure S33. HMBC spectrum of the new compound 11 Figure S34. COSY spectrum of the new compound 11 Figure S35. NOESY spectrum of the new compound 11 iii

4 Figure S1. HRESI-MS spectrum of the new compound 1 1

5 Figure S2. 1 H NMR (600 MHz, DMSO-d6) spectrum of the new compound

6 Figure S3. 13 C NMR (150 MHz, DMSO-d 6 ) spectrum of the new compound 1 3

7 Figure S4. HSQC spectrum of the new compound 1 4

8 Figure S5. HMBC spectrum of the new compound 1 5

9 Figure S6. COSY spectrum of the new compound 1 6

10 Figure S7. NOESY spectrum of the new compound 1 7

11 Figure S8. HRESI-MS spectrum of the new compound 2 8

12 Figure S9. 1 H NMR (600 MHz, DMSO-d6) spectrum of the new compound

13 Figure S C NMR (150 MHz, DMSO-d6) spectrum of the new compound

14 Figure S11. HSQC spectrum of the new compound 2 11

15 Figure S12. HMBC spectrum of the new compound 2 12

16 Figure S13. COSY spectrum of the new compound 2 13

17 Figure S14. NOESY spectrum of the new compound 2 14

18 Figure S15. HRESI-MS spectrum of the new compound 3 15

19 Figure S16. 1 H NMR (600 MHz, DMSO-d6) spectrum of the new compound 3 16

20 Figure S C NMR (150 MHz, DMSO-d 6 ) spectrum of the new compound 3 17

21 Figure S18. HSQC spectrum of the new compound 3 18

22 Figure S19. HMBC spectrum of the new compound 3 19

23 Figure S20. COSY spectrum of the new compound 3 20

24 Figure S21. NOESY spectrum of the new compound 3 21

25 Figure S22. HRESI-MS spectrum of the new compound 10 22

26 Figure S23. 1 H NMR (600 MHz, DMSO-d6) spectrum of the new compound 10 23

27 Figure S C NMR (150 MHz, DMSO-d6) spectrum of the new compound 10 24

28 Figure S25. HSQC spectrum of the new compound 10 25

29 Figure S26. HMBC spectrum of the new compound 10 26

30 Figure S27. COSY spectrum of the new compound 10 27

31 Figure S28. NOESY spectrum of the new compound 10 28

32 Figure S29. HRESI-MS spectrum of the new compound 11 29

33 Figure S30. 1 H NMR (600 MHz, DMSO-d6) spectrum of the new compound 11 30

34 Figure S C NMR (150 MHz, DMSO-d6) spectrum of the new compound 11 31

35 Figure S32. HSQC spectrum of the new compound 11 32

36 Figure S33. HMBC spectrum of the new compound 11 33

37 Figure S34. COSY spectrum of the new compound 11 34

38 Figure S35. NOESY spectrum of the new compound 11 35