Formation of Nudicaulins In Vivo and In Vitro and the Biomimetic Synthesis and Bioactivity of O-Methylated Nudicaulin Derivatives
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1 Formation of Nudicaulins In Vivo and In Vitro and the Biomimetic Synthesis and Bioactivity of O-Methylated Nudicaulin Derivatives Bettina Dudek 1,, Florian Schnurrer 1,, Hans-Martin Dahse 2, Christian Paetz 1, Anne-Christin Warskulat 1, Christiane Weigel 2, Kerstin Voigt 2 and Bernd Schneider 1, * 1 Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, D Jena, Germany; bdudek@ice.mpg.de (B.D.); fschnurrer@ice.mpg.de (F.S.); cpaetz@ice.mpg.de (C.P.); anne.warskulat@yahoo.de (A.-C.W.) 2 Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Adolf-Reichwein-Straße 23, D Jena, Germany; hans-martin.dahse@hki-jena.de (H.-M.D.); christiane.weigel@hki-jena.de (C.W.); kerstin.voigt@hki-jena.de (K.V.) * Correspondence: schneider@ice.mpg.de; Tel.: These authors contributed equally to this work. Supplementary Materials Table of content 1. Nudicaulin formation 3 2. NMR spectra 3 3. HR-MS UV/Vis absorption spectra CD spectrum Cell Toxicity Antimicrobial activity 28 Table of schemes, figures, and tables Scheme S1: Formation of nudicaulin derivatives from pelargonidin glucosides in P. nudicaule petals. Cyanidin, which possesses one additional hydroxyl group, can also form nudicaulin derivatives. 3 Figure S1: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 4 Figure S2: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 4 Figure S3: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d4) 5 Figure S4: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d4) 5 Figure S5: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA- MeOH-d4) 6 Figure S6: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 6 Figure S7: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 7 Figure S8: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d4) 7 Figure S9: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d4) 8 Figure S10: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA - MeOH-d4 8 Figure S11: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 9 Figure S12: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 9 Figure S13: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d4)10
2 Figure S14: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d4) 10 Figure S15: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA - MeOH-d4) 11 Figure S16: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 11 Figure S17: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 12 Figure S18: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d4)12 Figure S19: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d4) 13 Figure S20: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA - MeOH-d4) 13 Figure S21: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (10), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 14 Figure S22: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (8), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 14 Figure S23: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d4) 15 Figure S24: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d4)15 Figure S25: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (10), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA - MeOH-d4) 16 Figure S26: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 16 Figure S27: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d4) 17 Figure S28: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOHd4) 17 Figure S29: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOHd4) 18 Figure S30: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (10), 1 H- 1 H COSY spectrum (500 MHz, 1% - MeOH-d4) 18 Figure S31: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), mass spectrum 19 Figure S32: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), mass spectrum 19 Figure S33: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), mass spectrum 19 Figure S34: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), mass spectrum 20 Figure S35: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (10), mass spectrum 20 Figure S36: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), mass spectrum 20 Figure S37: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), UV/Vis spectrum (0.1 % TFA-MeOH) 21 Figure S38: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), UV/Vis spectrum (0.1 % TFA-MeOH) 21 Figure S39: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), UV/Vis spectrum (0.1 % TFA-MeOH) 22 Figure S40: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), UV/Vis spectrum (0.1 % TFA-MeOH) 22 Figure S41: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (10), UV/Vis spectrum (0.1 % TFA-MeOH) 23 Figure S42: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), UV/Vis spectrum (0.1 % TFA-MeOH) 23 Figure S43: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), CD spectrum (concentration 0.78 mg ml -1 (1.66 mm in MeOH), cuvette width 1 mm) 24 Figure S44: Dose response relationship for antiproliferative effect on HUVEC cells (72 h), Representative curves are given. 26 Figure S45: Dose response relationship values for antiproliferative effect on K-562 cells (72 h), Representative curves are given. 26 Figure S46: Dose response relationship values for cytotoxicity on HeLa cells (72 h), Representative curves are given. 27 Table S1: Antiproliferative and cytotoxicity data of compounds Table S2: Antimicrobial data of compounds
3 1. Nudicaulin formation Scheme S1: Formation of nudicaulin derivatives from pelargonidin glucosides in P. nudicaule petals. Cyanidin, which possesses one additional hydroxyl group, can also form nudicaulin derivatives.
4 2. NMR spectra Figure S1: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S2: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4)
5 Figure S3: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S4: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d 4)
6 Figure S5: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA- MeOH-d 4) Figure S6: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4)
7 Figure S7: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S8: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d 4)
8 Figure S9: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S10: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA - MeOH-d 4
9 Figure S11: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S12: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4)
10 Figure S13: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S14: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d 4)
11 Figure S15: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S16: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4)
12 Figure S17: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S18: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d 4)
13 Figure S19: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S20: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA - MeOH-d 4)
14 Figure S21: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (10), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S22: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (8), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4)
15 Figure S23: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S24: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (8), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d 4)
16 Figure S25: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (10), 1 H- 1 H COSY spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S26: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), 1 H-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4)
17 Figure S27: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), 13 C-NMR spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S28: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), 1 H- 13 C HSQC spectrum (500 MHz, 1% TFA - MeOH-d 4)
18 Figure S29: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), 1 H- 13 C HMBC spectrum (500 MHz, 1% TFA - MeOH-d 4) Figure S30: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (10), 1 H- 1 H COSY spectrum (500 MHz, 1% - MeOH-d 4)
19 3. HR-MS Figure S31: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), mass spectrum Figure S32: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), mass spectrum Figure S33: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), mass spectrum
20 Figure S34: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), mass spectrum Figure S35: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (10), mass spectrum Figure S36: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), mass spectrum
21 4. UV/Vis absorption spectra UV/Vis absorption spectra were acquired with the photodiode array detector (PDA) G1315B, nm of HPLC 1 (Chapter 4.1). Figure S37: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), UV/Vis spectrum (0.1 % TFA-MeOH) Figure S38: 16-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (7), UV/Vis spectrum (0.1 % TFA-MeOH)
22 Figure S39: 17-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (8), UV/Vis spectrum (0.1 % TFA-MeOH) Figure S40: 18-Methyl-5,7,11,3,4 -penta-o-methylnudicaulin (9), UV/Vis spectrum (0.1 % TFA-MeOH)
23 Figure S41: 17-Fluoro-5,7,11,3,4 -penta-o-methylnudicaulin (10), UV/Vis spectrum (0.1 % TFA-MeOH) Figure S42: 17-Hydroxy-5,7,11,3,4 -penta-o-methylnudicaulin (11), UV/Vis spectrum (0.1 % TFA-MeOH)
24 5. CD spectrum Figure S43: 5,7,11,3,4 -Penta-O-methylnudicaulin (6), CD spectrum (concentration 0.78 mg ml -1 (1.66 mm in MeOH), cuvette width 1 mm)
25 6. Cell Toxicity Table S1: Antiproliferative and cytotoxicity data of compounds 6-11 Antiproliferative activity Cytotoxicity Compound HUVEC K-562 HeLa GI 50 µmol l -1 GI 50 µmol l -1 CC 50 µmol l (± 0.2) 1.1 (± 0.4) 3.4 (± 0.4) (± 1.2) 1.4 (± 0.6) 5.8 (± 0.2) (± 1.9) 4.1 (± 0.6) 16.5 (± 1.4) (± 0.4) 2.9 (± 0.4) 8.4 (± 1.2) (± 0.6) 1.0 (± 0.2) 5.7 (± 0.2) (± 0.4) 1.0 (± 0.4) 5.5 (± 0.2) Imatinib * 22.1 (± 2.4) 0.2 (± ) 78.6 (± 2.8) Doxorubicin * (± 1.1) 3.68 (± 1.5) For structures of compounds 6-11, see Scheme II. * Chemotherapeutic drugs, values published in [23] Krauth, F.; Dahse, H.-M.; Rüttinger, H.-H.; Frohberg, P. Synthesis and characterization of novel 1,2,4-triazine derivatives with antiproliferative activity. Bioorg. Med. Chem. 2010, 18, , DOI /j.bmc
26 100 Antiproliferative Effect on HUVEC (72 h) Proliferation (% vs. Control) Concentration (µmol l -1 ) Control Figure S44: Dose response relationship for antiproliferative effect on HUVEC cells (72 h), Representative curves are given. 100 Antiproliferative Effect on K-562 (72 h) Proliferation (% vs. Control) Concentration (µmol l -1 ) Control Figure S45: Dose response relationship values for antiproliferative effect on K-562 cells (72 h), Representative curves are given.
27 Cytotoxicity on HeLa (72 h) 100 Viability (% vs. Control) Concentration (µmol l -1 ) Control Figure S46: Dose response relationship values for cytotoxicity on HeLa cells (72 h), Representative curves are given.
28 7. Antimicrobial activity Table S2: Antimicrobial data of compounds 6-11 Compound 6* 7* 8* 9* 10* 11* Ciproflaxacin*ricin MeOH Amphote- B*** c mg ml * *10-2 Bacillus subtilis 6633 B P Staphylococcus aureus 511 B P Escherichia coli 458 B / 32p 0 0 Pseudomonas aeruginosa SG137 B P. aeruginosa K799/61 B /37p 0 0 MRSA S. aureus 134/93 R P VRE Enterococcus faecalis 1528 R F 0 0 Mycobacterium vaccae M4 18p 14p 14p 15p 15p 18p 23p 0 0 Sporobolomyces salmonicolor 549 H p Candida albicans C. alb H Penicillium notatum JP36 P p For structures of compounds 6-11, see Scheme II. p = colonies in the inhibition zone; P = many colonies in the inhibition zone; A = indication of inhibition; F = promotion of growth * solution in MeOH ** solution in deionized water *** solution in DMSO/MeOH MRSA indicates methicillin-resistant Staphylococcus aureus VRE indicates vancomycin-resistant Enterococcus
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