What s in Happ-E-Mare?

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1 Happ-E-Mare Is This Your Mare? Anxious and upset Can t settle down Loss of focus Difficult to ride Always in heat Muscle sore Colic-like signs Irritable Stressed The only mare product to reduce mare issues that has High Dose Vitamin E, 8 herbs, 2 added vitamins, and minerals The only multi-herbal mare product you can show and race on Can use on mares and geldings to calm and relax 65% less cost than Regumate Money back guarantee to improve your mare s health and comfort All natural product to help your mare get off hormones and shots

2 Contents What s in Happ-E-Mare?... 3 General Mare Reproductive Information... 3 How Different From Humans... 4 Insulin Resistance Leads to Issues... 4 Why Foundering When in Heat?... 5 Thyroid Issues... 5 Anatomy Problems... 6 Transition Period Always in Heat... 6 Horse Calming Supplement for Nervousness Why It Works... 6 OK in Geldings & Stallions... 7 Can I Compete on Happ-E-Mare?... 7 Is Happ-E-Mare Free of Roundup?... 7 Is Happ-E-Mare Non GMO?... 7 How is Happ-E-Mare Better than Just Plain Raspberry Leaf?... 8 How is Happ-E-Mare Better than Regumate?... 8 Can My Jenny Be On Happ-E-Mare?... 9 Why is Happ-E-Mare a Powder and not a Pellet?... 9 Page 2 of 9

3 What s in Happ-E-Mare? Happ-E-Mare is a great tasting supplement for your mare you will have no troubles feeding this product. Happ-E-Mare contains unique combinations of: Herbs Eleuthero, ashwagandha, chastetree berry, USDA certified organic raspberry leaf, ginger, oregano, spirulina, chia, Boswellia, arginine, and MSM Added vitamins to help mare: o Vitamin B6 2 mg per dose o Vitamin E 2024 IU per dose Tested negative for Salmonella, E. coli and Listeria by the University of Pennsylvania Veterinary School Diagnostics Lab Tested negative for herbicides, drugs, and lead by the University of Pennsylvania Veterinary School Diagnostics Lab It is also non-gmo, gluten free, contains no added selenium, contains a special USDA certified organic raspberry leaf, and was tested free of aflatoxins by Midwest Labs Tested low in sugars and carbs by Equi-Analytical Labs in March 2018 (WSC 2.3, ESC 2.0, Starch 0.2) A mineral screen was performed by the University of Pennsylvania Veterinary School Diagnostics Lab (Tested lead, arsenic, and thallium free) Mineral Amount per Scoop (mg) Calcium 54.9 Copper 0.06 Iron 5.1 Manganese 0.75 Phosphorus 38 Potassium Selenium 0 Sodium 21.5 General Mare Reproductive Information Normal Estrous Cycle 1. Mare are long day, seasonally polyestrous breeders. As the days get longer (more light in a 24-hour period), they start cycling. As the days get shorter (in the autumn), they stop cycling. Their cycle lasts spring, summer, and early fall. In the late fall and winter, the mare is in anestrous there is no cycling. In the spring, they go through a transition phase, where they go from anestrous back to estrous cycling. This also occurs in the fall when they go out of estrous cycling. Page 3 of 9

4 These two transition phases will have an abnormal cycling times and that leads to a stressful time for mares it can last for days, but can be in and out of heat within only a few days for example. The usual estrus and diestrous days are not on schedule. They are irregular in timing, making behavioral patterns erratic. 2. In anestrus (late Fall & Winter), even though mares are not cycling, they often will have behavioral problems. They may be mildly receptive to a stallion still or even be fully receptive all winter. 3. Polyestrous means they will have many cycles during the long day times of the year each estrus cycle is 21 days long. For 4-6 days, a follicle forms on an ovary during estrus and mares are receptive to a stallion. For days, the mare is in diestrous where the corpus luteum forms on the ovary and the mare is not receptive to a stallion. 4. Control of estrus depends on control of hormones. In estrus, the main hormone is estrogen. In diestrous, the main hormone is progesterone. How Different From Humans Mares a different from humans! Mares will continue to have cycles in estrous throughout their lives there is NO menopause for mares! Mares do not menstruate. Often you will see products with PMS Formula technically this is not true since mares cannot get PMS. Some mares do have many of the signs of PMS, but it s important for owners to know this difference. Insulin Resistance Leads to Issues Insulin resistance will cause inability of the mare to get pregnant, can cause foal loss (abortion) or laminitis in the late stages of pregnancy. If your mare is prone to IR via genetics or eating patterns/diet, it can affect their behavior and estrus cycle pattern. Page 4 of 9

5 Why Foundering When in Heat? Often owners will comment that their mare started a laminitis bout when she started coming into heat. Why is this happening? 1. These mares are already IR (insulin resistant) and are on the edge of high blood insulin creating laminitis the start of their heat cycle is the final push over the cliffs edge. 2. There are several studies showing high amounts of estrogen can trigger insulin resistance in mare going into heat, estrogen levels are increasing and peaking. The exact mechanism of estrogen s effect on insulin resistance are still being studied (some studies conflict on findings), but here are 3 studies showing estrogen s ability to add to insulin resistance. A. Insulin Sensitivity is decreased in normal women on estradiol doses. 1. Estradiol supplemented decreases insulin sensitivity. 2. This effect was not in all subjects. Note from Dr. Reilly: This must suggest that this effect will not occur in all mares. B. Effect of Estrogen on Insulin Sensitivity. 1. Moderate estrogen doses may actually increase insulin sensitivity, but higher doses of it creates Insulin Resistance. Note from Dr. Reilly: Estrogen peaks early in heat cycle might be when we see problems in sore mares that are IR/prone to estrogen peak hyper insulin. C. Estrogen Given to Men Induced Insulin Resistance men given high dose estradiol. 2. Estradiol treatment in men can induce insulin resistance in healthy subjects. Note from Dr. Reilly: Using this hormone in a male and creating IR is strong evidence of estrogen having a role in insulin action. 3. Stress of Coming into Heat. Stress raises cortisol and that hormone interferes with normal insulin action, which creates an insulin surge to overcome this interference. If already IR, becomes very IR and laminitis triggered. Thyroid Issues Low Thyroid Hormone many mares will benefit from a combination of Happ-E-Mare and ThyroL powder. Have your vet test the mare s total T4 level. Often, they are SUBOPTIMAL and run at the bottom of the normal range we need them at the top of the normal range. 1-2 scoops (12-24 mg) of ThyroL can help bring your mare to the top of the normal range for optimal immunity and muscle health. Example: Test #1 T4 = 1.3 (where the normal range is 1-3) Page 5 of 9

6 Test #2 T4 on ThyroL = 2.7 (top of normal range) On tests, DO NOT ACCEPT it s normal we know that. Think of it this way: You get into a car accident and are taken to the hospital. Dr. A is 1 year out of school and has license. Dr. B is head of surgery, 30 years of experience, wrote 2 books on trauma and has license. BOTH are normal, but you know who you would choose. Anatomy Problems External Reproductive Tract Anatomy Problem: If your mare s vulva tilts inward, manure has a tendency to pour out onto her reproductive tract, which leads to urinary tract infections. The mare might urinate more often, feel poorly and not really care if a stallion is around this can lead to problems in gauging where she is in the estrus cycle. She may be resistant to being ridden and not be able to focus due to having an infection. These infections can also progress to uterine infections. Excess fluid and inflammatory cells build up in the uterus. Uterine infections lead to short cycling the time out of heat is very short, so she is in heat more often. Transition Period Always in Heat 1. Transition periods of abnormal estrus cycles 60 days in spring and 60 days in fall 2. Hormonal swings of coming into heat from progesterone to estrogen control There are approximately 11 estrus cycles a year, creating behavioral and physical changes in your mare. 3. Anestrus ( in heat ) abnormal issues mare is NOT to be cycling then, but many mares exhibit in heat signs in the winter. Horse Calming Supplement for Nervousness Why It Works Often, horses do not have a hormonal problem but still need a calming aid for their nervousness. Happ-E-Mare can help them by reducing inflammation, helping immunity, easing their stomachs and supporting muscles so they feel better. Sometimes nervousness is caused by discomfort. Happ-E-Mare is good to use in both mares and geldings! Page 6 of 9

7 OK in Geldings & Stallions Can I use Happ-E-Mare in geldings or stallions with Behavioral Issues? Does your gelding or stallion need a calming aid in order to handle, ride, turn out or train? Yes, you can use Happ-E-Mare! Many owners use Happ-E-Mare on horses that are sour acting, flighty or nervous. Can I use Happ-E-Mare in geldings or stallions in competition? Yes! It is now popular for owners to use Happ-E-Mare due to new regulations that makes Regumate illegal to race, show and compete on. But Happ-E-Mare is here to help! Can I Compete on Happ-E-Mare? Yes! Happ-E-Mare contains no prohibited herbs. In many mare products on the market, you can NOT use them for 14 days prior to events. Prohibited herbs in many mare products include chamomile, teas, comfrey, vervain, kava, passion flower, hops, valerian, skullcap, laurel, lavender, lemon balm, and devil s claw. Prohibited in competition, but it is listed in horse catalogs and online Be Careful! Brand A contains passion flower, chamomile Brand B contains vervain, chamomile Brand C contains passion flower, chamomile, valerian Brand D contains valerian Is Happ-E-Mare Free of Roundup? Happ-E-Mare is tested free of all herbicides, pesticides, drugs, and lead. You need this information to make fully informed decisions for your horses. Is Happ-E-Mare Non GMO? Happ-E-Mare is free of GMOs as well as gluten, and can be taken in conjunction with medications your mare may be prescribed to. Page 7 of 9

8 How is Happ-E-Mare Better than Just Plain Raspberry Leaf? Equianalytical Labs tested cut and sifted raspberry leaf and found it was high in ESC sugars 8.5% and extremely high in WSC (fructans) at 20.4%. Horses that are IR (insulin resistant), possible IR or Cushings (PPID) need to avoid straight raspberry leaf. See chart of differences in plain raspberry leaf and multi-dimensional Happ-E-Mare: Certified Organic Tested Low Carb Minerals Added Multiple Herbs Tested Free of Pesticides, Herbicides, Lead, and Drugs Free Vet Consults High Dose Vitamin E Tested Free of Aflatoxin Happ-E-Mare Y Y Y Y Y Y Y Y Raspberry Leaf Alone N N N N Unknown N N Unknown Winner: Happ-E-Mare Happ-E-Mare s raspberry leaf is 100% organic top grade, top quality and top safety. Herbicides with Raspberry Leaf. Happ-E-Mare tested negative for Herbicides. We make sure our source and amount of raspberry leaf is safe. With others, you may have no idea what types of herbicides, pesticides or chemicals the grower uses. Non-GMO Raspberry Leaf is in Happ-E-Mare. With others, you may have no idea whether the herb is GMO or non-gmo. Raspberry Leaf in Happ-E-Mare is USDA certified organic. Your horse deserves the best, and with others, you may have no idea if the herb is organic or not. How is Happ-E-Mare Better than Regumate? Regumate is a synthetic, progesterone-like oral hormone. Problem #1: Regumate is prescription only. You cannot get it at the store or online without a veterinary prescription. Happ-E-Mare is available in stores and online with no prescription. Problem #2: Regumate is $2.50 per dose. Happ-E-Mare is only $0.95 a dose if feeding over an 8 month period (spring to early fall), that s $372 in savings! Problem #3: Some mares have adverse reactions to Regumate. They can become more spooky, nervous or aggressive. Happ-E-Mare s all natural formula works to calm mares. Problem #4: Missing a dose of Regumate will result in your mare coming into heat. If you run out and skip a dose one or two times, your mare will come into heat. Restarting it will have no effect for at least a week. Happ-E-Mare will NOT cause hormonal crashes if a dose is missed. Page 8 of 9

9 Problem #5: Regumate is not approved in geldings. Happ-E-Mare is approved for use in geldings who need calming for better focus and better performance. Problem #6: Regumate is synthetic and contains no added herbs, minerals or vitamins. Happ-E- Mare is made from natural herbs, minerals and vitamins. Problem #7: Human contact with skin can result in hormonal imbalances in people. Regumate can be absorbed through the skin. Happ-E-Mare does not require gloves or protective clothing, is stable at hot or cold temperatures and has a 2-year shelf life, and there are no problems with handling or if it get on the skin. Can My Jenny Be On Happ-E-Mare? Yes, she can use Happ-E-Mare! They have the same reproductive cycles as mares. Happ-E-Mare can help them to be less anxious and nervous, and more comfortable. Donkeys are more prone to Insulin resistance if miniature you can use Happ-E-Mare and the Heiro program together! Many Jennies have reproductive problems if IR. If you plan on breeding your donkey, discontinue use of Happ-E-Mare, but continue the Heiro program through pregnancy and nursing. Why is Happ-E-Mare a Powder and not a Pellet? Happ-E-Mare has 9 natural herbs with no loss of potency from being processed with heat (200 F steamed heat) to produce a pellet. Pellets are hot when they leave the pellet die because of heat coming from steam conditioning. If Happ-E-Mare went through the extrusion process it would cook the herbs at 260 F Disclaimer: Happ-E-Mare is a supplement to help maintain health. Discuss supplements with your veterinarian. Happ-E-Mare is NOT for breeding, pregnant or nursing mares. The Happ-E-Mare program includes proper diet, exercise and sleep. Be sure to go to to view additional information and links. Page 9 of 9

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