AUTOCLAVABLE R&D FERMENTERS/ BIOREACTORS

Transcription

1 AUTOCLAVABLE R&D FERMENTERS/ BIOREACTORS

2 JUPITER is designed as fermenter/bioreactor suitable for beginner and experience user alike. It is therefore ideal for educational purposes. JUPITER meets your specific needs, it covers a wide range of applications and complies with the requirements of a validated GMP regulation. The PCS includes all the functions for parameters measurement and control: intelligent sensors, wireless connection, easy load pumps and aeration module conveniently located. It is designed for greater performance at a lower operating cost for your lab. The best ratio Quality/ Capability/Price on the market JUPITER is an ideal partner for microbial fermentation as well as animal, plant and insect cell cultivation. Typical applications includes the following: Education Basic research Scale-up and scale-down studies Process development and optimization WHY TO INVEST IN THIS PRODUCT SCADA Software Leonardo, with parallel control: up to 24 vessels managed from one station JUPITER can be used for: Biopharmaceutical Biofuels research and manufacturing Vaccines Food and beverage biotechnologies Bioremediation Bioplastics Cosmeceutical Nutraceutical 12 different volumes and D/H ratio

3 Benefits Vessels series User-friendly fermentation and cultivation management Innovative PARALLEL process control Remote control for after sale assistance Remote access via PC, tablet/smatphone Parallel parametres calibration do 2 and ph cascade control Up to 4 integrated pumps capable of operating in variable speed mode and additional externals brushless pumps Automatic gas mixing algorithms for simplified controls (4-gas, 3-gas, O 2 enrichment, N 2 enrichment) VESSEL Solaris with 12 different volumes and 7 diameter/height ratios has probably the most various range of standard bioreactor/ fermenters on the market, giving its clients the flexibility needed to find the right solution for their application. Compact PCS (350x350x350 mm). 23 touch display. Safety: pressure releaf valve included with every unit. Powerful brushless motors, from 1 to 2000 RPM. Online absorbed Torques (Nm) and Power (W) measurements obtaining an indirect density indication of the culture broth. Fully removable and cleanable jacket. Up to 24 vessels managed with one station. Modbus Hamilton sensors: ph, do 2, conductivity, redox. Four assignable peristaltic pumps, all speed controlled. Sterile sampling systems. External plug & play additional sensors: OD, dco 2, turbidity, weight, peristaltic pumps. Gax mixing up to 5 TMFC (Air, CO 2,N 2,O 2 and overlay).

4 Leda sampling system Gas mixing Sterile single use sampling system up to 180 sterile sampling per batch. Needlefree connector is designed to reduce the risk of contamination during sampling. Flat Split-septum Straight fluid path Various controller and hardware configurations enable aeration strategies using air, oxygen, nitrogen or a mixture of these to enrich the air. The mass-flow controller allows the exact flow rate control of individual gases. The flexible aeration options integrated in the fermenter/bioreactor permit a wide range of different application giving to this system a substantial versatility. Technical specifications Material Autoclavable Residual volume Flow rate VALOX resin (external) silicone (internal) C (up to 30 minutes) 0.04 ml 165 ml/minute Minimal deadspace Thermal Mass Flow Controller in entry model The sterile combination of a syringe ( ml) and a non return valve guarantee the sterility after sampling until the next use. Gas mixing through TMFC and solenoid valves or numbers of TMFC Automatic gas mixing algorithms for simplified controls (4-gas, 3-gas, O 2 enrichment, N 2 enrichment) Toro, fluted and sintered spargers

5 S Cube Leonardo 2.0 SOLARIS CUBE SERIES Why a Cube? Solaris new modular product design strategy decreases time to market and the number of unique parts in the product architecture increasing the number of product variants. The result is a lean, flexible and smart PCS. USER-FRIENDLY SOFTWARE The software is the user s best friend in experimental design planning and performing trial runs, as well as analyzing and optimizing media and parameters for cultivation. The graphical user interface enables you to select the software functions intuitively. Data extracted are compatible with Windows Excel. However, Solaris has developed a platform where to easily and quickly manage cultivation data. This software is included in the fermenter/bioreactor supply and can be installed on unlimited number of client s PC or laptop. WHAT COLOR SUITS YOU BEST? Do it parallel: smarter..faster Leonardo can be used for process development (i.e. time-saving parallel fermentation approaches) Up to 24 indipendent fermentations/cultivations can be carried out simultaneously. Parallel synoptic. Parallel trends comparison between units, current and old batches. Plug and Play modular additional parameters for future PCS upgrade including dco 2, Cell Density, Turbidity, weight, peristaltic pumps, ect. Do it wireless! Increased mobility: users can roam around lab or reaching office or home without losing their connection with the running batch.

6 Data sheet Controls Chiller Vessel Solaris Code Jupiter 2.0 Jupiter 3.0 Jupiter 3.1 Jupiter 4.0 Jupiter 4.2 Jupiter 4.5 Jupiter 5.0 Jupiter 5.5 Jupiter 6.0 Jupiter 7.0 Jupiter 8.0 Jupiter 10.0 Production Code A1 B1 A2 A3 B2 C1 A4 B3 C2 B4 C3 C4 Total Volume (liters) 2,00 3,00 3,10 4,00 4,20 4,50 5,00 5,50 6,00 7,00 8,00 10,00 Ratio D/H 1:2,0 1:1,5 1:2,5 1:3,0 1:2,0 1:1,5 1:4,0 1:2,5 1:2,0 1:3,5 1:2,0 1:3,0 Min. Working Volume (liters) 0,33 0,40 0,46 0,46 0,72 0,44 0,46 0,72 0,87 0,62 0,87 0,96 Max. Working Volume (liters) 1,50 2,25 2,25 3,00 3,15 3,40 3,75 4,00 4,50 5,25 6,00 7,50 Max. temperature C Operating pressure < 0,5 bar Temperature PT C ph Digital Hamilton sensor 0-14 Operation temperature C 0-6 bar Actuator Cascade to peristaltic pumps for the addition of acid/base solutions or gas (CO 2 ) Optionally JUPITER can be equipped with a chiller for heat removal from your culture minimizing lab water usage Using this system you don t need a water supply line in your lab Cost-effective cooling of fermenters Easy operation Refregerant level monitoring Headplate Ports (14) s lenght (mm) ph do₂ Dimensions for autoclave (with Condenser) Height (mm) Diameter (mm) Design n.1 port, Gas Sparger Input n.1 port, Gas overlay n.1 port, Gas out/condenser n.1 port, Sampling system n.1 port, Harvesting system n.1 port, Temperature sensor n.1 port, multiaddition (4) needle free connectors Borosilicate Glass Jacketed Vessel n.5 ports, spares, n.1 port, single addition needle free connectors, n.1 port, agitation group INTEGRATED IN S CUBE do 2 Digital Optical Hamilton sensor 0,05-300% air saturation Operation temperature C 0-12 bar Actuator Cascade to RPM, Gas Control, feedings,ect Antifoam/Level Control Redox (ORP) Operation temperature Solaris sensor Digital Hamilton sensor ±2000 mv C SAVE WATER Materials Borosilicate Glass and AISI 316 L 6 bar Stirring Conductivity Digital Hamilton sensor Drive Power Brushless Motor, Direct Assembly, rpm (bacterial), (cell cultures) 208 W Operation temperature µs/cm C Impellers Select from: Rushtons impellers, Marine Impellers, Pitched blade 0-20 bar Thermoregulation Control PID Control - Accuracy 0,1 C - Jacket water heater Gas Control & Gas Mixing dco 2 Mettler Toledo sensor Sparger and overlay Gas Control TMFC Gas Mixing (Air,CO 2,O 2,N 2 ) n.1 TMFC + n.4 solenoid valves, n of TMFC Sparger type Select from: Toro type (ring), syntered microbubbling both provided with 0,2 µm filter Exhaust Condenser and 0,2 µm filter Peristaltic Pumps up to 4 Watson Marlow 114, speed 0-60 rpm, volumetric flow 0,5-51 ml/min, application assignable from software n. 1 Watson Marlow 313 FDM/D, speed rpm, volumetric flow 1, ml/min, application assignable from software n. 1 Watson Marlow 520 FDM/R2, speed rpm, volumetric flow 1, ml/min, application assignable from software Controller Master Control Module from 1 to 24 units - Dimensions Height: 350 mm Largeness: 350 mm Depth: 350 mm HMI with Leonardo software 23 for single unit, 27 for multi system parallel EXTERNAL PLUG & PLAY BOX Operation temperature Cell density Option 1 Option 2 Weight Control Peristaltic pumps WM 114 WM 313 FDM/D WM 520 FDM/R2 0,00-200% saturation C 0-4 bar Hamilton-Fogale sensor Total cell density (Two ranges: 10^5 to 10^8 mammalian cells/ml to 300 g/l dry weight) Viable cell density (Two ranges: 5x10^5 to 8x10^8 mammalian cells/ml - 5 to 200 g/l dry weight) load cells 0-60 rpm rpm rpm Chiller data sheet Working temperature range -25 C / +100 C Temperature stability ±0.05 Heating power 1.5 kw Cooling output at 20 C kw Pump pressure max. 0.2 bar Pump flow max. 15 L/min. Bath volume L Bath opening 165x190 mm Bath depth 160 mm Cabinet height (mm) 605 Cabinet largeness (mm) 220

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