STANDARD STERILIZABLE IN PLACE SOLUTIONS
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1 STANDARD STERILIZABLE IN PLACE SOLUTIONS
2 GENESIS is R&D Sterizable-In-Place Benchtop Fermenter/Bioreactor available from 7,5 up to 20 litres total volume. Automatic sterilization through electric heaters (no need for an external steam source) or alternative by steam. The best ratio Quality/ Capability/Price on the market GENESIS is an ideal partner for microbial fermentation as well as animal, plant and insect cell cultivation. Typical applications includes the following: Education Basic research Scale-up and scale-down studies Process development and optimization GENESIS can be used for: Biopharmaceutical Biofuels research and manufacturing Vaccines Food and beverage biotechnologies Bioremediation Bioplastics Cosmeceutical Nutraceutical WHY TO INVEST IN THIS PRODUCT user friendly SCADA Software Leonardo Automatic sterilization through electrical heaters (no need for an external steam source) or by steam
3 Benefits User-friendly fermentation and cultivation management Innovative PARALLEL process control Remote control for after sale assistance Remote access via PC or tablet/smartphone do 2 and ph cascade control Up to four integrated pumps capable of operating in variable speed mode and additional externals brushless pumps Compact PCS (350x350x350 mm). 23 touch display. Modbus Hamilton sensors: ph, do 2, conductivity, redox. Powerful brushless motors, from 1 to 2000 RPM. Online absorbed Torques (Nm) and Power (W) measurements obtaining an indirect density indication of the culture broth. External plug & play additional sensors: OD, dco 2, turbidity, weight, peristaltic pumps. Sterile sampling systems. Gax mixing up to 5 TMFC (Air, CO 2,N 2,O 2 and overlay). Up to 24 vessels managed with one station. Four assignable peristaltic pumps, all speed controlled. Innovative system of immersed led illuminated videocamera that permits to display (on HMI) and record videos and photos inside the cultivation broth.
4 Leda sampling system Gas mixing Sterile single use sampling system up to 180 sterile sampling per batch. Needlefree connector is designed to reduce the risk of contamination during sampling. Technical specifications Material VALOX resin (external) silicone (internal) Autoclavable C (up to 30 minutes) Flat Split-septum Straight fluid path Minimal deadspace Various controller and hardware configurations enable aeration strategies using air, oxygen, nitrogen or a mixture of these to enrich the air. The mass-flow controller allows the exact flow rate control of individual gases. The flexible aeration options integrated in the bioreactor permit a wide range of different application giving to this system a substantial versatility. Thermal Mass Flow Controller in entry model Residual volume Flow rate 0.04 ml 165 ml/minute Gas mixing through TMFC and solenoid valves or numbers of TMFC Automatic gas mixing algorithms for simplified controls (4-gas, 3-gas, O 2 enrichment, N 2 enrichment) The sterile combination of a syringe ( ml) and a non return valve guarantee the sterility after sampling until the next use. Toro, fluted and sintered spargers
5 S Cube Leonardo 2.0 SOLARIS CUBE SERIES Why a Cube? Solaris new modular product design strategy decreases time to market and the number of unique parts in the product architecture increasing the number of product variants. The result is a lean, flexible and smart PCS. WHAT COLOR SUITS YOU BEST? USER-FRIENDLY SOFTWARE The software is the user s best friend in experimental design planning and performing trial runs, as well as analyzing and optimizing media and parameters for cultivation. The graphical user interface enables you to select the software functions intuitively. Data extracted are compatible with Window Excel. However, Solaris has developed a platform where to easily and quickly manage fermentation data. This software is included in the fermenter supply and can be installed on unlimited number of client s PC or laptop. Do it parallel: smarter..faster Leonardo can be used for process development (i.e. time-saving parallel fermentation approaches) Up to 24 indipendent fermentations/cultivations can be carried out simultaneously. Parallel workflows settings. Parallel trends comparison between units, current and old batches. Do it wireless! Increased mobility: users can roam around lab or reaching office or home without losing their connection with the running batch. Plug and Play modular additional parameters for future PCS upgrade including dco 2, Cell Density, Turbidity, weight, peristaltic pumps, ect
6 Data sheet Vessel Solaris Code Genesis 7.5 Genesis 10.0 Genesis 15.0 Genesis 20.0 Total Volume (liters) Ratio D/H 1:2,5 1:2,5 1:2,5 1:2,5 Min. Working Volume (liters) Max. Working Volume (liters) Working temperature range C Working pressure range < 0.5bar Design Stainless Steel Jacketed Vessel Materials Parts in contact with the culture AISI 316 L - other parts AISI 304 Ports and Connections Stirring Drive Power Impellers Thermoregulation Control Gas Control & Gas Mixing Sparger and overlay Gas Control Gas Mixing (Air,CO 2,O 2,N 2 ) Sparger type Exhaust Controller Master Controle Module Connection Quantity Description PG13,5 3 Sampling A.F. Spare (Camera housing) Safety Valve TC 3/4 2 Vessel lid Gas-out TK 3/4 1 SALAS - Solaris Sterile Liquid Addition System TC 1 2 Pressure probe Lamp DN52 1 Stirrer Upper side wall TC 1/2" 1 Overlay gas inlet TC 1/2" 1 Sparger In-gold 1 Spare (Camera, CO2, ) Lower side wall Hygienic socket 2 ph & do2 probes Temp. housing 1 PT100 Vessel bottom TC 3/4" 1 Harvest valve TC 1/2" 1 Steam In Jacket in-out TC 1/2" 1 Water in TC 1/2" 1 Jacket out 1/2" G 3 Electric Heaters in Brushless Motor, Direct Assembly, rpm (bacterial), (cell cultures) 266W Select from: Rushtons impellers, Marine Impellers, Pitched blade PID Control - Accuracy 0,1 C Jacket steam and electric heaters / cooling source TMFC n.1 TMFC + n.4 solenoid valves, n of TMFC Select from: Toro type (ring), syntered microbubbling both provided with 0,2 µm filter Condenser and 0,2 µm filter from 1 to 4 units - Dimensions Height: 350 mm Largeness: 350 mm Depth: 350 mm HMI with Leonardo software 9,7 Controls Temperature PT C ph Digital Hamilton sensor 0-14 Operation temperature C 0-6 bar Actuator Cascade to peristlatic pumps for the addition of acid/base solutions or gas (CO 2 ) do 2 Digital Optical Hamilton sensor 0,05-300% air saturation Operation temperature C Actuator dco 2 Operation temperature Turbidity Cell density Option 1 Option 2 Redox (ORP) Operation temperature Conductivity Operation temperature Weight Control Antifoam/Level Control 0-12 bar Cascade to RPM, Gas Control, feedings,ect Mettler Toledo sensor 0,00-200% saturation C 0-4 bar Mettler Toledo sensor g/l, FTU Hamilton-Fogale sensor Total cell density (Two ranges: 10^5 to 10^8 mammalian cells/ml to 300 g/l dry weight) Viable cell density (Two ranges: 5x10^5 to 8x10^8 mammalian cells/ml - 5 to 200 g/l dry weight) Digital Hamilton sensor ±2000 mv C 6 bar Digital Hamilton sensor µs/cm C 0-20 bar n.3 load cells Solaris sensor Chiller data sheet Working temperature range -25 C / +100 C Temperature stability ±0.05 Heating power Cooling output at 20 C Pump pressure max. Pump flow max. Bath volume Bath opening Bath depth Chiller Optionally GENESIS can be equipped with a chiller for heat removal from your culture minimizing lab water usage Using this system you don t need a water supply line in your lab Cost-effective cooling of fermenters Easy operation Refregerant level monitoring SAVE WATER 1.5 kw kw 0.2 bar 15 L/min L 165x190 mm 160 mm Cabinet height (mm) 605 Cabinet largeness (mm) 220
7 SOLARIS BIOTECHNOLOGY srl Via Bachelet, Porto Mantovano Mantova - Italy Phone: Fax: info@solarisgroup.org
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