DRUG STABILITY AN EVIDENCE REVIEW AND DEVELOPMENT OF A NATIONAL METHODOLOGY FOR STABILITY TESTING OF AGENTS AND DEVICES
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1 DRUG STABILITY AN EVIDENCE REVIEW AND DEVELOPMENT OF A NATIONAL METHODOLOGY FOR STABILITY TESTING OF AGENTS AND DEVICES Mr Tim Hills Nottingham University Hospitals NHS Trust On behalf of the BSAC OPAT Standards Work-stream on Devices Drug Stability and the Literature Review Working Group
2 Structure Prefilled and OPAT National Survey Results Literature Review BSAC Tender Project
3 OPAT Delivery and Drug Stability Self Administration IV infusion centre Healthcare worker delivered
4 Options for Self-administration Syringes, diluents and vials Bags, flow restrictors/pumps Pre-compounded syringes 24hr Syringe pumps Elastomeric devices
5 Pre-filled Devices Syringes Bolus and 24hr infusion Elastomeric pump: Reasonable options of all OPAT drugs (inc. vancomycin). 24hr infusion option available
6 Obtaining prefilled devices Local pharmacy sterile production department Under supervision of a pharmacist special (max 7 days) Supply requires a registered pharmacy Manufacturing licence (longer expiry but batch manufacturer and QC) Other NHS Trust production department Private/Homecare provider
7 Appropriate stability data Special licenced Dependent on opinion of specialist production pharmacist. Batch production Require manufacturers licence In agreement with local QC department (National QC standards 2011).
8 The Problem General knowledge of the available stability data in the OPAT community is poor. Data often not published as commercially sensitive. BSAC Stability work-stream
9 BSAC OPAT Drug Stability in Devices work-stream 1. Survey which drugs/devices UK centres would be keen to use. 2. Review the literature around stability. 3. Undertake stability testing to national standards where gaps in the literature exist and publish in the public domain.
10 Results of BSAC OPAT Stability Survey 120 responses from 52 Trusts In cases where multiple responses for a Trust were submitted Compared, reviewed and amalgamated to produce one organisational response. To amalgamate responses, each question was reviewed. If there was one or more positive response to a question the organisational response was marked as a positive. Only if all responses were answered in the negative was the amalgamated response marked as negative. All free-text comments were included in the organisational response. Final set of 52 survey responses for analysis.
11 No. Organisations Not for reproduction without permission Device and Method of Preparation of Antimicrobials Used in OPAT Services Syringes Infusion bags Syringe driver/electronic infusion device Elastomeric Device Nurse Patient All SPU
12 Drugs with Storage and/or Stability Data Reported by Organisations Not for reproduction without permission
13 Specific Antimicrobials that Organisations would like This slide is intentionally lacking detail! Due to current work programme can t give specific information However (and no surprise?!) Around beta lactams Narrow spectrum penicillins Cephalosporins Not for reproduction without permission
14 Available Papers
15 Not for reproduction without permission Literature Review Articles by therapeutic Group 117 antibacterial 6 antifungal 11 antiviral
16 Not for reproduction without permission Literature Review Decade of Publication No. Articles 1980s s s s 16
17 Literature Review Not for reproduction without permission
18 Literature Review None fully complied with the NHS QC Standards. Too few samples and/or tests Storage conditions esp. body worn 10% vs 5% degradation Investigation into degradation products Differences between UK and US standards Review/survey to be submitted for publication.
19 BSAC Stability Tender Awarded service to start September OPAT related antimicrobials/year 2-3 years Includes syringes/bags/at least two elastomerics Including paediatric conc. Meropenem Flucloxacillin +/- Buffer
20 Acknowledgements BSAC OPAT Standards Committee - Devices/Drug Stability Work-stream Sue Snape (Nottingham) Andrew Seaton (Glasgow) Mark Gilchrist (Imperial) Sanjay Patel (Southampton) Literature Review Working group Mark Gilchrist (Imperial) Abi Jenkins (BSAC) Mark Santillo (QC South West)
Drug Stability : Update and future plans. Tim Hills Nottingham University Hospitals NHS Trust On behalf of the BSAC Working Party on Drug Stability
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