Noticias News Nouvelles. Total: 2800!!!

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Noticias News Nouvelles The Centre for Mother, Infant, and Child Research Sunnybrook Health Sciences Centre C8-2075 Bayview Avenue, Toronto ON CANADA M4N 3M5 Tel: 1 416 480 5639 Fax: 1 416

INSIDE THIS ISSUE Recruitment Complete Thank you messages 1 2 On April 1st we reached our recruitment goal!! Recruitment is now closed!

1 Noticias News Nouvelles The Centre for Mother, Infant, and Child Research Sunnybrook Health Sciences Centre C Bayview Avenue, Toronto ON CANADA M4N 3M5 Tel: Fax: tbs@sw.ca website: V O L U M E 1 0, I S S U E 3 M A R C H 3 1, Total: 2800!!! Total in March: 42 Recruitment Complete! INSIDE THIS ISSUE Recruitment Complete Thank you messages 1 2 On April 1st we reached our recruitment goal!! Recruitment is now closed! We could not have reached this milestone without your continued dedication and commitment to the study. Congratulations to everyone on a job well done! Data Campaign 3 Reminder: Ethics approvals Special Recognition Recruitment Excellence Recruitment Table 5 2yr Table 8

PAGE Message from Jon Barrett Dear friends, It is with many emotions that I write this note. The first are gratitude and humility to all of you who have made this momentous day possible.

There is just a little sadness because it means we are at the end of a chapter which has allowed us to become like a family.

2 PAGE Message from Jon Barrett Dear friends, It is with many emotions that I write this note. The first are gratitude and humility to all of you who have made this momentous day possible. None of this could have happened without you! And from all those at CMICR and me personally, a huge THANK YOU. There is just a little sadness because it means we are at the end of a chapter which has allowed us to become like a family. The third is a lot of pride in our achievement; together we have successfully completed a landmark piece of scientific work--the impact of this work will outlive all of us! Finally, I am sure we share the excitement as we get all the data returned to us to be analyzed. We hope to see you all at the final results meeting next year! From all of us at CMICR: 2

3 PAGE 3 RECRUITMENT IS FINISHED! PLEASE SEND US YOUR DATA TODAY! Data Campaign Please send all outstanding data, unanswered queries, and overdue supporting documents, to the Data Coordinating Centre today! If you expect delays, please contact us by as soon as possible to let us know. Reminder: Ethics Renewals Although the Twin Birth Study is now closed for recruitment, we still have to complete the 2 year follow-up phase of the study. As a result, we still need to have a copy of your current ethics approval at the Data Coordinating Centre. Please continue to submit the protocol to your local Research Ethics Board for renewal when it is due, and send a copy of the approval letter to us. Thank you for your cooperation with this.

PAGE 4 Special Recognition We wish to acknowledge Dr Maria De la Calle and the team at Hospital La Paz in Madrid, Spain for recruiting the 2800th patient into the study!

4 PAGE 4 Special Recognition We wish to acknowledge Dr Maria De la Calle and the team at Hospital La Paz in Madrid, Spain for recruiting the 2800th patient into the study!! Recruitment Excellence Congratulations to Dr Mario Palermo and the team at Hospital Posadas, Buenos Aires, Argentina; Dr Raquel de Lourdes Martin and the team at Hospital LC Lagomaggiore, Mendoza, Argentina; Dr Raul Abalos Gorostiaga and the team at Hospital Ramon Carrillo, Santiago del Estero, Argentina; Dr Renato Augusto Moreira de Sa and the team at Maternidade Escola da UFRJ, Rio de Janeiro, Brazil; Dr Jose Guillherme Cecatti and the team at University of Campinas, Campinas, Brazil; Dr Mordechai Hallak and the team at Hillel Yaffe Medical Center, Hadera, Israel; Dr Dalia Mansour-Schwake and the team at Holy Family Hospital, Nazareth, Israel; Dr Maria de la Calle and the team at Hospital La Paz, Madrid, Spain and Mr Kim Hinshaw and the team at City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK. Keep up the excellent work! We will be sending a gold seal to place on your Certificate of Achievement. Happiness lies in the joy of achievement and the thrill of creative effort. ~Theodore Roosevelt

5 P A G E 5 Twin Birth Study Recruitment (Projected sample size of 2800) March 31, 2011 Annual Jun Jul - Jan Feb Mar Grand Goal Total COUNTRY ARGENTINA BRAZIL CANADA ISRAEL POLAND UK CHILE SPAIN EGYPT AUSTRALIA THE NETHERLANDS SERBIA USA JORDAN JAMAICA ESTONIA QATAR HUNGARY OMAN ROMANIA BELGIUM GERMANY URUGUAY CROATIA GREECE Total CENTRES BY COUNTRY (Shaded area is prior to start-up) ARGENTINA Hospital LC Lagomaggiore, Mendoza Hospital Ramon Carrillo, Santiago del Estero Hospital Posadas, Buenos Aires Hospital Avellaneda, Tucuman Hospital JR Vidal, Corrientes Hospital Sarda, Buenos Aires Hospital Penna, Bahia Blanca Hospital Angela Iglesia de Llano, Corrientes Hospital Juan A Fernandez, Buenos Aires Hospital Alvarez, Buenos Aires Hospital JM Cullen, Santa Fe Centre(s) that are no longer recruiting 0 10 BRAZIL University of Campinas, Campinas Maternidade Escola da UFRJ, Rio de Janeiro University of Pernambuco, Recife Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo Hospital Universitario de Jundiai, Jundiai Hospital Sao Lucas, Porto Alegre Hospital Universitario Antonio Pedro, Niteroi Perinatal, Rio de Janeiro ISCMPA-Maternidade Mario Totta, Porto Alegre Botucatu Medical School, Botucatu Hospital Materno Infantil, Goiania Hospital das Clinicas da UFPE, Recife Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife 8 1 1

6 P A G E 6 Annual Jun Jul - Jan Feb Mar Grand Goal Total CANADA Sunnybrook Health Sciences Centre, Toronto IWK Health Centre, Halifax Regina General Hospital, Regina Trillium Health Centre, Mississauga Lion's Gate Hospital, Vancouver St Joseph's Health Care, London Foothills Medical Centre, Calgary SMBD Jewish General Hospital, Montreal Royal University Hospital, Saskatoon North Bay General Hospital, North Bay Royal Columbian Hospital, New Westminster Toronto East General, Toronto Children's & Women's Health Centre of BC, Vancouver St Paul's Hospital, Vancouver Centre(s) that are no longer recruiting 0 36 ISRAEL Nazareth Hospital (EMMS), Nazareth Ma'ayney HaYeshua Medical Center, Bnei Brak Edith Wolfson Medical Center, Holon Holy Family Hospital, Nazareth HaEmek Medical Center, Afula Poriya Government Hospital, Tiberias Hillel Yaffe Medical Center, Hadera Bnai Zion Medical Center, Haifa POLAND University School of Medical Sciences, Poznan Polish Mother's Memorial Hospital, Lodz Medical University of Gdansk, Gdansk UK Bradford Royal Infirmary, Bradford Nottingham City Hospital, Nottingham Basildon & Thurrock University Hospital, Basildon Liverpool Women's Hospital, Liverpool Derriford Hospital, Plymouth Queen's Medical Centre, Nottingham City Hospitals Sunderland NHS Foundation Trust, Sunderland Queen Elizabeth Hospital, King's Lynn University Hospital of North Staffordshire, Stoke-on-Trent Lewisham Hospital, London CHILE Hospital Dr Gustavo Fricke, Vina del Mar Hospital Dr Sotero del Rio, Puente Alto SPAIN Hospital Clinic-University of Barcelona, Barcelona Hospital La Paz, Madrid Hospital Vall d'hebron, Barcelona Complejo Hospitalario de Toledo, Toledo EGYPT Assiut University Hospital, Assiut AUSTRALIA Ipswich Hospital, Ipswich Mater Mothers' Hospital, Brisbane St George Hospital, Sydney Toowoomba Base Hospital, Toowoomba Monash Medical Centre, Clayton Logan Hospital, Meadowbrook Women's and Children's Hospital, Adelaide Townsville Hospital, Townsville THE NETHERLANDS Atrium Medical Center, Heerlen Academisch Ziekenhuis Maastricht, Maastricht Maxima Medical Centre, Veldhoven Sint Lucas Andreas Ziekenhuis, Amsterdam Centre(s) that are no longer recruiting 0 7

7 P A G E 7 Annual Goal Jul - Jun Jan Feb Mar Grand Total SERBIA University of Belgrade, Belgrade USA East Bay Perinatal Medical Associates, Oakland Maricopa Medical Center, Phoenix University of Miami, Miami University of South Carolina, Columbia University of Iowa Hospitals and Clinics, Iowa City Centre(s) that are no longer recruiting 0 4 JORDAN Islamic Hospital, Amman JAMAICA University Hospital of the West Indies, Kingston ESTONIA Tartu University Hospital - Women's Clinic, Tartu QATAR Hamad Medical Corporation, Doha HUNGARY University of Debrecen, Debrecen OMAN Khoula Hospital, Muscat ROMANIA University of Pharmacy and Medicine, Cluj-Napoca BELGIUM Centre(s) that are no longer recruiting 0 15 GERMANY Ludwig Maximilians University of Munich, Munich CUB - Virchow Klinikum, Berlin CUB - Benjamin Franklin, Berlin URUGUAY Pereira Rossell Hospital, Montevideo CROATIA Centre(s) that are no longer recruiting 0 9 GREECE Centre(s) that are no longer recruiting 0 4 Centres awaiting first patient: [COUNTRY: Hospital, City (annual goal)] [month/year start-up package sent] UK: AberdeenMaternity,Aberdeen (6) [11/06];

8 P A G E 8 TBS 2 Year Follow-up The status of the TBS 2 Year Follow-up is displayed in the following table for centres that recruited patients. Centres arelistedaccordingtothetotal number of recruits by country andcentre. Seebelowfor thenumber of follow-up assessments performed by your centre! Let's aim for 100% follow-up!! Status Totals As of March 2011 COUNTRY ARGENTINA BRAZIL CANADA ISRAEL POLAND UK CHILE SPAIN EGYPT AUSTRALIA THE NETHERLANDS SERBIA USA JORDAN JAMAICA ESTONIA QATAR HUNGARY OMAN ROMANIA GERMANY BELGIUM URUGUAY CROATIA GREECE Total % 91.8% 87.7% 83.4% 82.3% 69.2% 4.7% 50% CENTRES BY COUNTRY (Shaded area is prior to start-up) ARGENTINA Hospital LC Lagomaggiore, Mendoza Hospital Ramon Carrillo, Santiago del Estero Hospital Posadas, Buenos Aires Hospital Avellaneda, Tucuman Hospital JR Vidal, Corrientes Hospital Sarda, Buenos Aires Hospital Penna, Bahia Blanca Hospital Angela Iglesia de Llano, Corrientes Hospital Juan A Fernandez, Buenos Aires Hospital Ramos Mejia, Buenos Aires Hospital Alvarez, Buenos Aires Hospital JM Cullen, Santa Fe BRAZIL University of Campinas, Campinas Maternidade Escola da UFRJ, Rio de Janeiro University of Pernambuco, Recife Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo Hospital Universitario de Jundiai, Jundiai Hospital Sao Lucas, Porto Alegre Hospital Universitario Antonio Pedro, Niteroi Perinatal, Rio de Janeiro ISCMPA-Maternidade Mario Totta, Porto Alegre Botucatu Medical School, Botucatu Hospital Materno Infantil, Goiania Hospital das Clinicas da UFPE, Recife Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife 1 1 CANADA Sunnybrook Health Sciences Centre, Toronto IWK Health Centre, Halifax McMaster University Medical Centre, Hamilton Regina General Hospital, Regina Trillium Health Centre, Mississauga Lion's Gate Hospital, Vancouver St Joseph's Health Care, London Mount Sinai Hospital, Toronto Foothills Medical Centre, Calgary SMBD Jewish General Hospital, Montreal North Bay General Hospital, North Bay Royal University Hospital, Saskatoon Royal Columbian Hospital, New Westminster Toronto East General, Toronto Children's & Women's Health Centre of BC, Vancouver 1 1 York Central Hospital, Richmond Hill 1 1 St Paul's Hospital, Vancouver 1 1 ISRAEL Nazareth Hospital (EMMS), Nazareth Ma'ayney HaYeshua Medical Center, Bnei Brak Edith Wolfson Medical Center, Holon Holy Family Hospital, Nazareth HaEmek Medical Center, Afula Poriya Government Hospital, Tiberias Hillel Yaffe Medical Center, Hadera Bnai Zion Medical Center, Haifa POLAND Univ School of Medicine, Poznan Polish Mother's Memorial Hospital, Lodz Medical University of Gdansk, Gdansk

9 P A G E 9 Status Totals As of March 2011 UK Bradford Royal Infirmary, Bradford Nottingham City Hospital, Nottingham Basildon & Thurrock University Hospital, Basildon Liverpool Women's Hospital, Liverpool Derriford Hospital, Plymouth Queen's Medical Centre, Nottingham City Hospitals Sunderland NHS Foundation Trust, Sunderland Queen Elizabeth Hospital, King's Lynn University Hospital of North Staffordshire, Stoke-on-Trent Lewisham Hospital, London 3 3 CHILE Hospital Dr Gustavo Fricke, Vina del Mar Hospital Dr Sotero del Rio, Puente Alto SPAIN Hospital Clinic-University of Barcelona, Barcelona Hospital La Paz, Madrid Hospital Vall d'hebron, Barcelona Complejo Hospitalario de Toledo, Toledo EGYPT Assiut University Hospital, Assiut AUSTRALIA Ipswich Hospital, Ipswich Mater Mothers' Hospital, Brisbane St George Hospital, Sydney Toowoomba Base Hospital, Toowoomba Monash Medical Centre, Clayton Logan Hospital, Meadowbrook Women's and Children's Hospital, Adelaide Townsville Hospital, Townsville THE NETHERLANDS Atrium Medical Center, Heerlen Academisch Ziekenhuis Maastricht, Maastricht Maxima Medical Centre, Veldhoven Maaslandziekenhuis Sittard, Sittard Sint Lucas Andreas Ziekenhuis, Amsterdam SERBIA University of Belgrade, Belgrade USA East Bay Perinatal Medical Associates, Oakland Maricopa Medical Center, Phoenix University of Miami, Miami University of South Carolina, Columbia Jamaica Hospital Medical Center, Jamaica Texas Tech UHSC, Lubbock 2 2 University of Iowa Hospitals and Clinics, Iowa City JORDAN Islamic Hospital, Amman JAMAICA University Hospital of the West Indies, Kingston ESTONIA Tartu University Hospital - Women's Clinic, Tartu QATAR Hamad Medical Corporation, Doha HUNGARY University of Debrecen, Debrecen OMAN Khoula Hospital, Muscat ROMANIA University of Pharmacy and Medicine, Cluj-Napoca GERMANY Ludwig Maximilians University of Munich, Munich CUB - Virchow Klinikum, Berlin 3 3 CUB - Benjamin Franklin, Berlin BELGIUM Vrije Universiteit Brussel, Brussels URUGUAY Pereira Rossell Hospital, Montevideo CROATIA Sveti Duh Hospital, Zagreb GREECE Alexandra Maternity, Athens 1 3 4

Noticias News Nouvelles

Recruitment Tips Noticias News Nouvelles Volume 6 Issue 7 July 31, 2007 University of Toronto Maternal, Infant and Reproductive Health Research Unit at the Women s College Research Institute 7 th Floor,