Data Mining Data is logged every 3 hours 11 parameters : 1. Number of call 2. Correspondents and calls pattern 3. Call duration 4. Circle of friend 5.

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8 Data Mining Data is logged every 3 hours 11 parameters : 1. Number of call 2. Correspondents and calls pattern 3. Call duration 4. Circle of friend 5. Total time 6. GPS location analysis (delta) and total distance accumulated 7. Data usage sum of transferred data without analyzing content 8. Text message use - sms log - without analyzing content 9. Wi-Fi connection which network user is connected to 10. Device open and lock number of times 11. Application usage patterns open & close, duration (without app name)

9 Trust Buddy (TB) Concept A Trust buddy is a family member or a friend, chosen by the patient, who accepts their request. The Trust buddy will be the one who receives a signal if a significant change from normal patterns occurs

10 Trust Buddy(TB) Concept

11 Not Privacy, Anonymity Moving from privacy to complete Anonymity There is no identification of the patient. The only connection is through TB . The data that we gather on the patient is quantity and not qualities, (e.g. total distance accumulated and not GPS exact location)

12 What is unique about ifeel 1. No language barrier - Based on statistical data. 2. No cultural barrier - Use each individual behavioral pattern as baseline. 3. No issue of compliance - Once downloaded it uses information that stored anyhow on the back of the smartphone. 4. Empowering patients and families - Providing clinically relevant information in real time- for their combat depression tool box.

13 What is unique about ifeel 5. Potential of secondary prevention via early detection. 6. Free and not any hidden commercial agenda.(developed by scientific bodies in collaborations of patients and families organizations ). 7. clinical research Prospective and ongoing rigorous scientific clinical research will be an integral part along with its self learning engine will ensure constant improvement. 8. Privacy- Moving from privacy to complete Anonymity

14 Care giver communicative layer Allow patient to sign a chosen care giver for study purposes. At the end of a therapy meeting with the care giver the patient will press the "care giver button" in the app - a link to patient feedback form in ifeel minisite will be sent automatically to care giver mail.

15 Care giver communicative layer Enable care giver feedback on ifeel minisite - the feedback page will be updated on the website and assigned to the corresponding patient s database. Allows care giver to follow patient status and graphs through ifeel minisite Insure patient privacy (the only identify data is only related to CG)

16 ifeel Next Step 2015 Beta version 2017 Research and data mining 2019 Free App and post marketing Surveillance 2016 RND and Research platform 2018 RCT field trial

17 Additional layers for the field study : "Alert red button" layer Allow patient to sign a more the one trust buddy's up to four trust buddy's. When patient choose "1" on the VAS, (Visual Analog Scale), the system will recognize it as call for help "pushing the red button" and will send all the trust buddy's an indicate the situation, allowing the trust buddy's to make an informed intervention. Following the alert the system will send all trust buddy's link to patient feedback form in ifeel minisite, encouraging them to add more data on patient status. Enable all trust buddy's to fill a feedback form on ifeel minisite - the feedback page will be updated on the website and assigned to the corresponding patient s database. Insure patient privacy (the only identify data is only related to TB)

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