Basic values of ozone-therapy

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1 Basic values of ozone-therapy by Dr. med. Horst Kief Presentation in Istanbul Okt 2012

2 Energy gain in the brakedown of fermentation compared to the energy gain in oxygen metabolism k c a l anaerobic glycolysis O2-metabolism 2

3 mm Hg Oxygenpartial pressure determination of different water qualities = blank value aqua bidist. fauced water Anti-osmosis filtrate time (min) 3

mv Redox potential (mv) of different water qualities 1000 900 800 700 600 500 400 300 200 100 0 0 5 10 15 20 25

4 mv Redox potential (mv) of different water qualities müg ozon concentration 0 = blank value Aqua bidist. faucet water Anti-osmosis filtrate time (min) 4

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7 Change of redox equivalents under different O3- therapies 0,8 0,6 0,515 time between application and control :1 hour 0,626 0,672 0,4 0,25 0,265 0,2 0-0,2-0,208-0,4-0,318-0,6-0,602-0,629-0,52-0,8 n = 60 D0 D1 D2 D3 D4 D0 - D4 = Dulutions in powers of 10 of an erythrocyte lysate by ozonolysis 7

8 Change of redox equivalents under different O3-therapies time: 10 min. 0,6 0,4 n = 140 n = 8 n = 26 0,2 0 O35 O29 O491-0,2-0,4-0,6 035 = little auto haemotherapy according to Windstosser 029 = i.m.injection 049 = hyperbaric 03-therapy 8

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11 mmhg Po mm Hg 773,6 mm Hg erythrocytes concentrate venous blood clear plasma arterial blood

12 1 = blank value: Venous blood 2 = major autohemotherapy with O2/O3 3 = Venous blood after treatment as per [ 2 ] 4 = hyperbaric ozone therapy 5 = Venous blood after treatment as per [ 4 ] 6 = blank value: Arterial blood 7 = Arterial blood after hyperbaric O 3 -therapy 8 = Arterial blood after hyperbaric O 3 -therapy by arterial reinfusion 9 = blank value: Erythrocytes concentrate 10 = major autohemotherapy vol. blood : gas = 3 : 1 11 = major autohemotherapy vol. blood : gas = 1 : 1 12 = hyperbaric ozone-therapy 13 = hyperbaric extracorporeal O 2 -therapy 14 = blank value blood plasma 15 = major autohemotherapy vol. Plasma : gas = 3 : 1 16 = clear O 2 vol. plasma : gas = 1: 1 17 = major autohemotherapy vol. plasma : gas = 1 : 1 18 = hyperbaric ozone-therapy vol. plasma : gas = 1 : 1 Highest value 773,6 mmhg at

13 Effect of hyperbaric O3-therapy on cholesterol in vivo Dr. Kief

14 Effect of hyperbaric O3-therapy on cholesterol in vivo Dr. Kief

15 Sideeffects on Liverenzyms on the same population 15

16 Sideeffects on Liverenzyms on the same population 16

17 Sideeffects on Liverenzyms on the same population 17

18 Treatment of chronic Hepatitis by hyperbaric O3 therapy transminases initials SGOT SGPT Gamma GT cah* before react. after before react. after before react. after N. Th Sch. H Sch. E Z. K. H H. Kl K. F W. K G. K S. E R. C H. H M. H. J H. H P. J O. K Gl. E L. K Sch. J R. B A. O G. J B. K SGOT SGPT Gamma GT average value diffusion t-test 3, degr.of fr. 4, degr.of fr. 3, degr.of fr. (p<0,002) (p<0,001) (p<0,01) cah* before react. after before react. after before react. after average value diffusion * (cah = chronic aggressive hepatitis, histological evidence) 18

19 Treatment of chronic hepatitis with hyperbaric O3-therapy Blanc value Reactive phase result Dr. Kief

20 The formation of hydrogen peroxide by neutrophils 20

21 The killing of Staphylococcus by neutrophils 21

22 Some Abnormal Ozonization Reactions 22

23 OKT 4 absolute (thousand) Hyperbaric ozone-therapy treatment of ARC- and AIDS-patients 1,1 1 0,9 0,8 0,7 0,6 0,5 0,4 0,3 0,2 0,1 0 before therapy spectrum average +/- stand. deviation Δ after therapy n=15 23

24 OKT 8 relative Hyperbaric ozone-therapy treatment of ARC- and AIDS-patients 65,0% 60,0% 55,0% 50,0% 45,0% 40,0% 35,0% 30,0% 25,0% 20,0% before therapy spectrum average +/- stand. deviation Δ after therapy n=15 24

25 Quotient OKT4/OKT8 Hyperbaric ozone-therapy treatment of ARC- and AIDS-patients 1,5 1,4 1,3 1,2 1,1 1 0,9 0,8 0,7 0,6 0,5 0,4 0,3 0,2 0,1 before therapy spectrum average +/- stand. deviation Δ after therapy n=15 25

26 OKT 8 relative Hyperbaric ozone-therapy treatment of ARC- and AIDS-patients 70% 60% 50% 40% 30% before therapy 20% 10% after therapy 0% P. G. S. R. R. H. I. P. N. H. M. D. A. H. K. D. P. M. B. V. Sch. Th. initials P. A. H. A. V. S. M. V. 26

27 Hyperbaric O3-therapy and AHIT on HIV+ patients T4 600 T4 values Median and Quantiles Kief clinic (N=30) Q Med Q1 0 first Examination Patients with two or more Values were included in this analysis last 27

28 Hyperbaric O3-therapy and AHIT on HIV+ patients T8 values Median and Quantiles Kief clinic (N=30) T Q Med Q first Examination Patients with two or more values were included in this analysis last 28

29 Hyperbaric O3-therapy and AHIT on HIV+ patients T4/T8 ratio Median and Quantiles Kief Clinic (N=30) 0,8 T4/T8 0,6 Q3 0,4 Med Q1 0,2 0 first Examination Patients with two ore more Values were included in this analysis last 29

30 Hyperbaric O3-therapy and AHIT on HIV+ patients T8 values Median and Quantiles Kief and Sacher clinics (N=164) T Q Med Q first Examination Patients with two ore more values were included in this analysis last 30

31 Hyperbaric O3-therapy and AHIT on HIV+ patients T4 values Median and Quantiles Kief and Sacher Clinics (N=164) T Q3 400 Med Q first Examination Patients with two ore more Values were included in this analysis last 31

32 Hyperbaric O3-therapy and AHIT on HIV+ patients T4/T8 ratio Median and Quantiles Kief and Sacher Clinics (N=164) T4/T8 0,8 0,6 Q3 0,4 Med Q1 0,2 0 first Examination Patients with two ore more Values were included in this analysis last 32

33 Hyperbaric O3-therapy and AHIT on HIV+ patients T4/T8 ratio AHIT in comparison with no AHIT Kief and Sacher clinics (N=164) vs. Conservative treatment (AZT) (N=20) 0,4 T4/T8 0, AHIT Conservative treatment ,2 P = ,1 mean observation time Kief+Sacher: 414 days cons. treatm. (AZT): 363 days 0 first Examination last Patients with 2 or more values were included in this analysis (p-value of the Wilcoxon U-test) 33

34 Hyperbaric O3-therapy and AHIT on HIV+ patients T4/T8 ratio AHIT in comparison with no AHIT Kief Clinic (N=30) vs. conservative treatment (AZT) (N=20) 0,4 T4/T8 0, Kief ,2 P = P= ,1 mean observation time Kief: 291 days cons. treatm. (AZT): 363 days 0 first Examination last Patients with 2 ore more values were included in this analysis (p-value oft the Wilcoxon U-test) 34

CPM - THOUSANDS Reverse transcriptase activity supernatant cultures 30 25 20 uninfected control 15

35 CPM - THOUSANDS Reverse transcriptase activity supernatant cultures uninfected control 15 infected - no ozone 10 infected - 45µg/ml O3 5 infected - 55 µg/ml O days 35

36 Effect of 1g Vitamin C in 500 ml old Transfusionblood PO venous blood µg ozon µg ozon + vitamin C up to 3 times with O2-O3 mix admitted 36

37 Vitamin C and Dehydroascorbic Acid 37

38 Effect of hyperbare ozonetherapy on leucocytes from immunsupressed patients 38

39 Comparison: leucocytes in peripheral blood with hyperbaric Ozone therapy (+1g vitamin C) (malignant patients) 39

40 redox concentration in venous blood in mval/l Redox concentration in venous blood before and after hyperbaric ozone therapy 11, ,5 10 9,5 patients with malignancy (n=8) other diagnoses (n=17) 9 8,5 8 prior to therapy in vitro after therapy 40

41 redox concentration in venous blood in mval/l Redox concentration in venous blood before and after hyperbaric ozone therapy 11, ,5 10 9,5 patients with malignancy (n=13) other diagnoses (n=35) 9 8,5 8 prior to therapy after therapy 41

42 Interactions between ozone and other medications 42

43 1. Vitamin C -Repairs 2-3-DPG-shunt, enhances the O2-saturation of old erythrocytes -Reduces the tendency for fermentation of some malignancies 43

44 Sideeffects: If patients has a tendency for diabetic metabolism it can introduce a reversible diabetes. 44

45 2. Vitamin E - Protects cellmembrans against free radicals - Reduces haemolysis of high dosages of ozone at the major autohaemotherapy - Must be given in the therapy interval - 24h before therapy 45

46 3. Nitrofurantoin - Produces together with ozone hydroxylanions (OH. ) - NFT and O3 are together a really potent cytostatic - Has the same sideeffcts like strong cytostatics if long time used: neuropathy especially - Has compared to classic cytostatics less shorttime sideeffects like nausea, weakness etc. - Look on the drug information is necessary 46

47 For long time ozone- treatment are trace minerals nessecary 47

48 - Se ++ for Selenperoxydase 300 mg/day - Mn ++ for Mangansuperoxydismutase 5-10 mg/day - Zn ++ for Zinksuperoxydismutase 40mg/day 48

49 Thank you for your attention

Section Three Gas transport

Section Three Gas transport Lecture 6: Oxygen transport in blood. Carbon dioxide in blood. Objectives: i. To describe the carriage of O2 in blood. ii. iii. iv. To explain the oxyhemoglobin dissociation